Lower Respiratory Tract Infections Managed in Primary Care in France

NCT07416266 | Completed

• 1 other identifier: LRTI-20152024
• Study Type: observational
• Target: 230,066
• Locations: 0 countries
• Sites: N/A

Brief Summary

Primary aim: To describe participant characteristics at the time of the index lower respiratory tract infection (LRTI) episode in adults managed in primary care in France, using anonymized electronic health records from routine clinical practice between January 2015 and December 2024. Secondary aims: To describe and quantify patterns of antibiotic prescribing (rate, type, and duration of treatment) and short-term outcomes, including LRTI-related reconsultations and severe complications within 30 days after the index consultation. The overall objective is to better characterize real-world management and outcomes of lower respiratory tract infections in primary care and to identify potential areas for improving quality of care and optimizing antibiotic stewardship.

Conditions

Lower Respiratory Tract Infections; Community Acquired Pneumonia (CAP); Acute Bronchitis; Acute Exacerbation Chronic Obstructive Pulmonary Disease; Influenza

Keywords

Primary Care; Antimicrobial Stewardship; Electronic Health Records

Outcome Measures

Primary Outcomes (1)

• Participant Characteristics at Index LRTI Episode

  Descriptive summary of participant characteristics at the index lower respiratory tract infection episode, including age, sex, body mass index, smoking status, alcohol use, comorbidities, and vaccination status, overall and by antibiotic exposure group.

  Index consultation

Secondary Outcomes (5)

• Antibiotic Prescribing Rate

  Index consultation

• Type of Antibiotics Prescribed for Antibiotic-treated LRTIs

  Index consultation

• Duration of Antibiotic Treatment for Antiobiotic-treated LRTIs

  Index consultation

• 30-Day LRTI-Related Reconsultation Rate

  30 days

• 30-Day Severe Complication Rate After LRTI

  30 days

Study Arms (2)

Antibiotic-Treated LRTI

Adults with a recorded community-acquired lower respiratory tract infection (LRTI) in primary care in France between January 2015 and December 2024 whose index episode was associated with an antibiotic prescription during routine care. No intervention was assigned by the study.

Non-Antibiotic-Treated LRTI

Adults with a recorded community-acquired lower respiratory tract infection (LRTI) in primary care in France between January 2015 and December 2024 whose index episode was not associated with an antibiotic prescription during routine care. No intervention was assigned by the study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (≥18 years) with a recorded episode of community-acquired lower respiratory tract infection (LRTI) in French primary care between January 1, 2015 and December 31, 2024, identified from anonymized electronic health records in the THIN France database. Patients were required to have at least 12 months of prior medical history before the index episode.

You may qualify if:

• Age ≥18 years
• Recorded diagnosis of community-acquired lower respiratory tract infection in primary care between Jan 1, 2015 and Dec 31, 2024
• At least 12 months of medical history available before the index consultation

You may not qualify if:

• Age \<18 years
• Less than 12 months of medical data before index date

Sponsors & Collaborators

• Hôpital Raymond Poincaré: lead
• University of Lausanne Hospitals: collaborator
• Clinityx by Gers Data: collaborator
• Versailles Saint-Quentin-en-Yvelines University: collaborator

MeSH Terms

Conditions

Community-Acquired Pneumonia; Bronchitis; Influenza, Human

Condition Hierarchy (Ancestors)

Community-Acquired Infections; Infections; Pneumonia; Respiratory Tract Infections; Respiratory Tract Diseases; Bronchial Diseases; Lung Diseases, Obstructive; Lung Diseases; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2026
• First Posted: February 18, 2026
• Study Start: January 1, 2015
• Primary Completion: December 31, 2024
• Study Completion: January 9, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share