NCT07414901

Brief Summary

The proposed study will evaluate the effectiveness of an integrated group postpartum and well-child care model, compared to individual (usual) postnatal and well-child care, on maternal and child health outcomes. Results will provide clinical evidence for improved maternal and infant health care in the first year postpartum. The study will inform and provide lessons learned to advance maternal and infant health service delivery models in low resource settings.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,125

participants targeted

Target at P75+ for not_applicable

Timeline
46mo left

Started Mar 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

16 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress1%
Mar 2026Jan 2030

First Submitted

Initial submission to the registry

February 11, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 17, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

March 30, 2026

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2029

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 30, 2030

Last Updated

April 15, 2026

Status Verified

April 1, 2026

Enrollment Period

3.7 years

First QC Date

February 11, 2026

Last Update Submit

April 10, 2026

Conditions

Outcome Measures

Primary Outcomes (2)

  • Postpartum depression score as measured by the Edinburgh Postnatal Depression Scale (EPDS)

    The EPDS is a 10-item self-report scale with scores ranging from 0-30; higher scores indicate more depressive symptoms.

    baseline, 6 months, and 12 months postpartum

  • Infant immunization completion rate per national immunization schedule

    6 months, and 12 months after birth

Secondary Outcomes (17)

  • Number of participants using a family planning method

    baseline, 6 months and 12 months postpartum

  • Number of Participants who recall postnatal care content as measured by structured survey

    6 and 12 months postpartum

  • Self-reported peer connectedness as measured by study survey

    6 and 12 months postpartum

  • Breastfeeding self-efficacy as measured by the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF)

    baseline, 6 months and 12 months postpartum

  • Number of Participants Exclusively breastfeeding at 6 months after birth

    6 months postpartum

  • +12 more secondary outcomes

Study Arms (2)

Group Care

EXPERIMENTAL
Behavioral: Group Care

Usual care

NO INTERVENTION

Interventions

Group CareBEHAVIORAL

Group care in the postpartum period brings the same group of 8-10 women and their infants, born within one month of one another, together for one year of integrated healthcare for the dyad. Sessions are co-facilitated by a midwife and HSA. Each session is 120 minutes: first 30-45 minutes consist of self-assessments (measuring infant's weight/length, taking own vital signs) and standard health assessments by a clinician; health concerns are identified/managed and referrals made if needed. Followed by 75-90 minutes of interactive health promotion, skills-building, and support activities. 6-visit model aligned with Malawian vaccine schedule: 6 weeks, 10 weeks, 14 weeks, 6 months, 9 months, and 12 months.

Group Care

Eligibility Criteria

Age1 Week - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Aims 1\&2:
  • Women presenting for their 1-week postnatal care visit with their infant at a study site clinic.
  • Over age 15.
  • One infant is less than 4 weeks old.
  • Able to speak and understand Chichewa.
  • Adolescents 15-17 must bring parent/guardian for consent/assent. Infants included as part of mother-infant dyad.
  • Aim 3:
  • Midwife or HSA serving as group care co-facilitator or key stakeholders in MoH/Zomba District/clinical administration
  • Able to speak Chichewa and/or English.

You may not qualify if:

  • Aim 1\&2
  • Under age 15.
  • Serious physical or mental illness or marked cognitive impairment preventing informed consent.
  • Inability to participate in full intervention
  • Multiple infants (e.g. twins, triplets)
  • Aim 3
  • Serious physical or mental illness or marked cognitive impairment preventing informed consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (16)

Bimbi HC

Zomba, Malawi

NOT YET RECRUITING

Chamba HC

Zomba, Malawi

RECRUITING

Chingale HC

Zomba, Malawi

NOT YET RECRUITING

Domasi HC

Zomba, Malawi

NOT YET RECRUITING

Lambulira HC

Zomba, Malawi

NOT YET RECRUITING

Likangala HC

Zomba, Malawi

NOT YET RECRUITING

M'mambo HC

Zomba, Malawi

NOT YET RECRUITING

Machinjiri HC

Zomba, Malawi

NOT YET RECRUITING

Maera HC

Zomba, Malawi

NOT YET RECRUITING

Makwapala

Zomba, Malawi

NOT YET RECRUITING

Matawale HC

Zomba, Malawi

NOT YET RECRUITING

Mwandama HC

Zomba, Malawi

NOT YET RECRUITING

Naisi HC

Zomba, Malawi

RECRUITING

Namasalima HC

Zomba, Malawi

NOT YET RECRUITING

Nasawa

Zomba, Malawi

NOT YET RECRUITING

Ngwelero HC

Zomba, Malawi

NOT YET RECRUITING

Study Officials

  • Ashley Gresh

    Johns Hopkins University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 11, 2026

First Posted

February 17, 2026

Study Start

March 30, 2026

Primary Completion (Estimated)

November 30, 2029

Study Completion (Estimated)

January 30, 2030

Last Updated

April 15, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations