Association Between Dynamic Prealbumin Trajectories and Prognosis in Critically Ill Patients

NCT07414160 | Not Yet Recruiting

• 1 other identifier: PAB-TRACK
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

Nutritional support therapy is a crucial part of ICU patient care, as both malnutrition and overnutrition can lead to adverse clinical outcomes. Meticulous monitoring of nutritional support is essential. Unfortunately, to date, there are no biomarkers available to assess the appropriateness of nutritional support in the ICU setting. However, mounting evidence suggests that phenotypic analysis of patients using nutritional biomarkers or risk screening scores for adaptation may enhance our ability to characterize patients in terms of prognosis and likelihood of treatment response. This study aims to identify the trajectory patterns of prealbumin changes based on dynamic monitoring data of prealbumin during hospitalization of critically ill patients, and to analyze the Association between different trajectory groups and patient prognosis. In addition, this study will further analyze its Association with nutritional intake and nutritional indicators, thereby assessing the potential value of prealbumin change trajectories in terms of the adequacy and effectiveness of nutritional support for critically ill patients.

Conditions

ICU; Critical Illness; Adult

Keywords

prealbumin; Critically Ill Patients; Prognosis

Outcome Measures

Primary Outcomes (1)

• ICU mortality

  Death from any cause occurring during the index ICU stay

  From ICU admission (Day 1) through ICU discharge or death, whichever occurs first (up to 28 days).

Secondary Outcomes (16)

• In-hospital mortality

  From ICU admission (Day 1) through hospital discharge or death, whichever occurs first (up to 28 days).

• ICU-acquired infection

  From ICU admission (Day 1) through ICU discharge or death, whichever occurs first (up to 28 days).

• ICU length of stay

  From ICU admission (Day 1) through ICU discharge or death, whichever occurs first (up to 28 days).

• Ventilator-free days through Day 28

  28 days after ICU admission

• Vasopressor-free days during ICU stay

  From ICU admission (Day 1) through ICU discharge or death, whichever occurs first (up to 28 days).

Study Arms (1)

Critically ill adults admitted to the ICU

Age \> 18 years, SOFA score ≥ 2, and at least three prealbumin data points within the previous 14 days. Exclusion criteria: patients with liver failure, kidney failure, hereditary amyloidosis and Alzheimer's disease, long-term use of hormones, or NSAIDs.

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

No study-specific intervention is assigned. Participants receive usual clinical care as determined by the treating team

Critically ill adults admitted to the ICU

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to the ICU of Jilin University First Hospital.

You may qualify if:

• age \> 18 years,
• SOFA score ≥ 2
• at least three prealbumin data points within the previous 14 days.

You may not qualify if:

• patients with liver failure
• patients with kidney failure,
• hereditary amyloidosis and Alzheimer's disease
• long-term use of hormones or NSAIDs. -

Sponsors & Collaborators

• The First Hospital of Jilin University: lead

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• dong zhang

  The First Hospital of Jilin University

  STUDY CHAIR

Central Study Contacts

Yanhua Li

CONTACT

15804301738; liyanhua@jlu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: chief physician

Study Record Dates

• First Submitted: February 5, 2026
• First Posted: February 17, 2026
• Study Start: March 15, 2026
• Primary Completion (Estimated): March 15, 2027
• Study Completion (Estimated): April 15, 2027
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share