Serum Talin-1 and Cripto-1 in Colorectal Cancer

NCT07414082 | Not Yet Recruiting

• 1 other identifier: SHROOK
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The goals of this study are

• To evaluate the clinical utility of Talin-1 and Cripto-1 measurement in colorectal cancer patients in comparison with healthy controls.
• To Compare the diagnostic significance of serum Talin-1 and Cripto-1 with traditional serum biomarker CEA

Conditions

Colo-rectal Cancer

Outcome Measures

Primary Outcomes (1)

• Serum Talin-1 measurement in colorectal cancer patients

  measuring serum level of talin-1 in colorectal cancer patient to compare its level with healthy control

  From enrollment up to one week

Secondary Outcomes (1)

• Serum Cripto-1 measurement in colorectal cancer patients

  From enrollment up to one week

Study Arms (1)

Group(1)

EXPERIMENTAL

Diagnostic Test: Serum level of Human Talin-1; Diagnostic Test: Serum level of Human Cripto-1

Interventions

Serum level of Human Talin-1 DIAGNOSTIC_TEST

To evaluate the clinical utility of Talin-1 measurement in colorectal cancer patients in comparison with healthy controls.

Group(1)

Serum level of Human Cripto-1 DIAGNOSTIC_TEST

To evaluate the clinical utility of Cripto-1 measurement in colorectal cancer patients in comparison with healthy controls.

Group(1)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>18 years Old.
• Patients of both sexes who met the clinical diagnostic criteria of colorectal cancer (change in bowel habit, absolute or recurrent constipation, rectal bleeding, significant weight loss or intestinal obstruction)
• Patients diagnosed with colorectal cancer by imaging and histopathology

You may not qualify if:

• Age \<18 years old.
• Patients with past history of chemotherapy or surgical excision of tumor
• Patients with familial adenomatous polyposis
• Patients with hereditary non-polyposis colorectal cancer
• Patients with inflammatory bowel disease
• patients with other types of tumors

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assuit University Hospital

Asyut, Asyut Governorate, 17777, Egypt

Location

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Central Study Contacts

Sherouk Ahmed Sayed, Assistant lecturer

CONTACT

+201123232632; shrookabozaid@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: January 24, 2026
• First Posted: February 17, 2026
• Study Start: March 30, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: February 17, 2026

Record last verified: 2026-01

Locations

EG (1)