Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty

NCT07410000 | Recruiting

• 1 other identifier: Bursa City Hospital 14
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective, randomized, double-blind study evaluates the analgesic effectiveness of the ultrasound-guided Quadro-Iliac Plane (QIP) block in patients undergoing primary total hip arthroplasty. The QIP block is a recently described fascial plane block. Patients will be randomized to receive either a QIP block with local anesthetic or a sham block with saline. The primary outcome is 24-hour opioid consumption. Secondary outcomes include motor block, dermatomal sensory assessment, pain scores, rescue analgesic requirement, quality of recovery (QoR-15), and opioid-related side effects.

Conditions

Pain Management; Total Hip Arthroplasty

Keywords

Total Hip Arthroplasty; Postoperative Analgesia; Quadro-Iliac Plane Block

Outcome Measures

Primary Outcomes (1)

• Postoperative 24-Hour Morphine PCA Consumption

  Total amount of morphine delivered by the patient-controlled analgesia (PCA) device during the first 24 hours after surgery, recorded in milligrams (mg).

  Postoperative 24 hours

Secondary Outcomes (5)

• NRS Pain Scores at Rest and Movement

  2, 6, 12, 24, and 48 hours postoperatively

• QoR-15 Recovery Score

  QoR-15 Recovery Score will be evaluated at the postoperative 48th hour

• Lower Extremity Muscle Strength Score

  Postoperative 6th and 12th hours

• Rescue Analgesic Requirement

  Postoperative 0-48 hours

• Opioid-Related Side Effects

  Postoperative 0-48 hours

Study Arms (2)

Quadro-Iliac Plane (QIP) Block

EXPERIMENTAL

Participants in this arm will receive the standard analgesia protocol used for patients undergoing total hip arthroplasty. In addition to this standard regimen, an ultrasound-guided Quadro-Iliac Plane (QIP) block will be performed in the preoperative period with the patient in the lateral decubitus position. The technique aims to provide postoperative analgesia by achieving sensory blockade in the relevant dermatomal areas.

Procedure: Quadro-Iliac Plane (QIP) Block

Sham Block (Control)

PLACEBO COMPARATOR

Participants in this arm will receive the standard analgesia protocol used for patients undergoing total hip arthroplasty. In addition to this standard regimen, a sham block will be performed using the same ultrasound-guided technique and patient positioning to mimic the block procedure without providing active regional anesthesia.

Procedure: Sham Block

Interventions

Quadro-Iliac Plane (QIP) Block PROCEDURE

An ultrasound-guided Quadro-Iliac Plane block performed in the preoperative period. At the level of the iliac crest, 40 mL of a solution containing 0.25% levobupivacaine and 5 µg/mL epinephrine is injected into the fascial plane between the erector spinae muscle and the quadratus lumborum muscle under aseptic conditions.

Also known as: QIP Block

Quadro-Iliac Plane (QIP) Block

Sham Block PROCEDURE

A sham block performed using the same ultrasound-guided technique in the preoperative period. At the level of the iliac crest, 40 mL of 0.9% NaCl is injected into the fascial plane between the erector spinae muscle and the quadratus lumborum muscle under aseptic conditions.

Also known as: Control Block

Sham Block (Control)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• American Society of Anesthesiologists (ASA) classification I-III
• Age between 18 and 80 years
• Patients scheduled for elective primary total hip arthroplasty

You may not qualify if:

• Refusal to participate in the study
• Allergy to local anesthetics or opioids
• Known or suspected coagulopathy
• Infection at the injection site
• History of previous hip surgery
• Severe cardiovascular disease
• Liver or kidney failure
• Pregnancy, suspected pregnancy, or breastfeeding
• Severe neurological or psychiatric disorder
• Chronic opioid use

Sponsors & Collaborators

• Bursa City Hospital: lead

Study Sites (1)

Bursa City Hospital

Bursa, 16110, Turkey (Türkiye)

RECRUITING

Related Publications (5)

• Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017 Sep 25;10:2287-2298. doi: 10.2147/JPR.S144066. eCollection 2017.

  PMID: 29026331 BACKGROUND

• Carella M, Beck F, Piette N, Denys S, Kurth W, Lecoq JP, Bonhomme VL. Effect of suprainguinal fascia iliaca compartment block on postoperative opioid consumption and functional recovery in posterolateral-approached total hip arthroplasty: a single-blind randomized controlled trial. Reg Anesth Pain Med. 2022 Jun 15:rapm-2021-103427. doi: 10.1136/rapm-2021-103427. Online ahead of print.

  PMID: 35705263 BACKGROUND

• Marrone F, Sorrentino T, Pullano C, Tulgar S. A novel and feasible option for perioperative analgesia in hip fractures surgery: quadro-iliac plane block. Minerva Anestesiol. 2025 Jun;91(6):592-595. doi: 10.23736/S0375-9393.25.18801-9. Epub 2025 Mar 27. No abstract available.

  PMID: 40145906 BACKGROUND

• Tulgar S, Ciftci B, Ahiskalioglu A, Bilal B, Sakul BU, Girit M, Akin T, Narayanan M, Alici HA. Ultrasound guided quadro-iliac plane block: another novel fascial plane block. Pain Med. 2024 May 3;25(6):370-373. doi: 10.1093/pm/pnae018.

  PMID: 38459608 BACKGROUND

• Selvi O, Azizoglu M, Temel G, Tulgar S, Chitneni A, Cinar EN, Ozer Z, Gurkan Y. Translation and Validation of the Turkish Version of the Quality of Postoperative Recovery Score QoR-15: A Multi-Centred Cohort Study. Turk J Anaesthesiol Reanim. 2022 Dec;50(6):443-448. doi: 10.5152/TJAR.2022.21417.

  PMID: 36511494 BACKGROUND

MeSH Terms

Conditions

Agnosia

Interventions

Dental Occlusion

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dentistry; Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Central Study Contacts

Mursel Ekinci, Assoc prof,MD

CONTACT

+905067137596; drmurselekinci@gmail.com

Mustafa Dikici, MD

CONTACT

+905055346540; mus.dikici88@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The study solutions will be prepared by an anesthesiologist who is not involved in patient care or data collection. The anesthesiologist performing the block and the patient will be blinded to group allocation. Postoperative assessments will be performed by an independent anesthesiologist who is also blinded
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Study Record Dates

• First Submitted: February 7, 2026
• First Posted: February 13, 2026
• Study Start: March 16, 2026
• Primary Completion (Estimated): February 15, 2027
• Study Completion (Estimated): March 15, 2027
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)