Trials Sponsors Conditions Drugs Pricing

Conditions

Anesthetic Efficacy

Outcome Measures

Primary Outcomes (1)

Anesthetic efficacy
Description: Patients will be assigned to one of the two groups . Group 1: 2%Lignocaine 1;80,000 epinephrine 1.8 ml IANB Group 2: 4%Articaine 1:100,000 epinephrine 1.8 ml Primary buccal infilteration Efficacy will be considered if there are 2 consecutive non-responsive readings during 60 mins duration , usually measured on EPT 15 mins after administration of anesthesia . Any pain felt during the procedure will be measured according to Heft-Parker VAS and moderate-severe pain reported (VAS ≥ 55) will be regarded unsuccessful . Time Frame: 1 hour after administration of local anesthetic agent .
1 hour after administration of anesthetic agent

Secondary Outcomes (1)

Duration of anesthesia
1 hour 30 mins

Study Arms (2)

ARM 1 : 2%Lignocaine 1:80,000 epinephrine

ACTIVE COMPARATOR

: 2% Lignocaine Inferior Alveolar Nerve Block (IANB) Participants in this group will receive an inferior alveolar nerve block using 2% Lignocaine with 1:80,000 epinephrine.

Other: INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrine

ARM 2 : 4% Articaine with 1:100,000 epinephrine

ACTIVE COMPARATOR

Participants in this group will receive 4% Articaine with 1:100,000 epinephrine at the site of the mandibular first molar.

Other: INTERVENTION 2 : 4%Articaine 1:100,000 epinephrine

Interventions

INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrineOther

2% Lignocaine Inferior Alveolar Nerve Block (IANB) : Participants in this group will receive an inferior alveolar nerve block using 2% Lignocaine with 1:80,000 epinephrine. The injection will be administered following standard IANB technique for mandibular first molars. The anesthetic efficacy will be assessed with 2 consecutive non responsive readings on EPT objectivelt and via Heft-Parker VAS not more than ≥55 .

ARM 1 : 2%Lignocaine 1:80,000 epinephrine

INTERVENTION 2 : 4%Articaine 1:100,000 epinephrineOther

Eligibility Criteria

Age18 Years - 55 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64)

You may qualify if:

Systemically healthy patients classified as ASA I, aged 18-55 years.
Permanent mandibular first molar tooth requiring endodontic therapy.

Sponsors & Collaborators

Armed Forces Institute of Dentistry, Pakistan
Otherlead

Study Sites (1)

Armed Forces Institute of Dentistry AFID CMH Rawalpindi

Rawalpindi, Punjab Province, 46000, Pakistan

RECRUITING

Sadia Shehzadi, BDS, FCPS Resident PGY3CONTACT03342073051 sadiashehzadi321@gmail.com

MeSH Terms

Interventions

LidocaineEpinephrine

Intervention Hierarchy (Ancestors)

AcetanilidesAnilidesAmidesOrganic ChemicalsAniline CompoundsAminesEthanolaminesAmino AlcoholsAlcoholsBiogenic MonoaminesBiogenic AminesCatecholaminesCatechols

Central Study Contacts

Dr. Sadia Shehzadi Dr. Sadia Shehzadi, BDS,FCPS(PG3)

CONTACT

03342073051 sadiashehzadi321@gmail.com

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Masking Details: Participants will be blinded to the type of local anesthetic technique administered. They will not be informed whether they received an IANB with 2% Lignocaine or Buccal Infilteration with 4% Articaine. The operator and investigator can not be blindeddue to the nature of the procedure.
Purpose: HEALTH SERVICES RESEARCH
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Dr. Sadia Shehzadi

Study Record Dates

First Submitted

December 7, 2025

First Posted

February 13, 2026

Study Start

March 20, 2026

Actual (reported)

Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (2)

ARM 1 : 2%Lignocaine 1:80,000 epinephrine

ARM 2 : 4% Articaine with 1:100,000 epinephrine

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (2)

ARM 1 : 2%Lignocaine 1:80,000 epinephrine

ARM 2 : 4% Articaine with 1:100,000 epinephrine

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations