Association Between Slow Wave Activity and Sleep Inertia

NCT07409883 | Not Yet Recruiting

• 1 other identifier: MURA2026/53
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Observational study: The goal of this observational study is to learn about the association between slow wave activity before awakening and post-awakening psychomotor vigilance task in time-fixed, 2-hour, simulated night naps in healthy individuals. The main question aims to answer is: Is the quantity of slow wave activity immediately before awakening associated with post-awakening psychomotor vigilance task metrics when awakened after 2-hour nap at night?

Conditions

Sleep, Slow-wave Sleep, Sleep Enhancement, Sleep Optimization; Sleep Inertia; Night Shift Work

Keywords

sleep inertia; nap

Outcome Measures

Primary Outcomes (1)

• psychomotor vigilance test (PVT)

  To investigate the association between slow wave activity (SWA) as assessed by electroencephalographic power spectral analysis during the last 10 minutes before awakening and a 10-minute psychomotor vigilance test (10-min PVT) immediately after awakening and 30 minutes after awakening in healthy participants on simulated night shifts

  Psychomotor vigilance test (PVT) will be assessed 2 times: 1) immediately after awakening, and 2) at 30 minutes after awakening.

Study Arms (1)

Nap intervention

Behavioral: Nap intervention

Interventions

Nap intervention BEHAVIORAL

Nap intervention is the protocol that allows the participant to sleep from 11:00 PM to 2:00 AM, then woken up.

Nap intervention

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy volunteers aged between 18 and 60 years, without significant sleep deprivation

You may qualify if:

• Age between 18 and 60 years
• History of appropriate sleep duration at least 6 hours/night for a minimum of 2 weeks assessed by sleep diary before the trial

You may not qualify if:

• STOP-BANG ≥3 or previous diagnosis of obstructive sleep apnea
• Presence of restless legs syndrome as assessed with IRLSSG criteria
• Presence of depression as assessed by HADS (Exclude participants with HADS-Depression sub-scale score ≥8 (possible depression)
• History of irregular work hours or shift work within 2 weeks
• Use of sedative/hypnotic medications on a regular-basis (3 days/week or above)
• History of epilepsy and brain tumor

Sponsors & Collaborators

• Mahidol University: lead
• Ramathibodi Hospital: collaborator

Study Sites (1)

Faculty of Engineering, Mahidol University

Nakhon Pathom, 73170, Thailand

Location

Related Publications (9)

• Signal TL, van den Berg MJ, Mulrine HM, Gander PH. Duration of sleep inertia after napping during simulated night work and in extended operations. Chronobiol Int. 2012 Jul;29(6):769-79. doi: 10.3109/07420528.2012.686547.

  PMID: 22734577 RESULT

• Achermann P, Werth E, Dijk DJ, Borbely AA. Time course of sleep inertia after nighttime and daytime sleep episodes. Arch Ital Biol. 1995 Dec;134(1):109-19.

  PMID: 8919196 RESULT

• Hilditch CJ, McHill AW. Sleep inertia: current insights. Nat Sci Sleep. 2019 Aug 22;11:155-165. doi: 10.2147/NSS.S188911. eCollection 2019.

  PMID: 31692489 RESULT

• Tassi P, Bonnefond A, Engasser O, Hoeft A, Eschenlauer R, Muzet A. EEG spectral power and cognitive performance during sleep inertia: the effect of normal sleep duration and partial sleep deprivation. Physiol Behav. 2006 Jan 30;87(1):177-84. doi: 10.1016/j.physbeh.2005.09.017. Epub 2005 Nov 21.

  PMID: 16303153 RESULT

• Dinges D, Orne M, Orne E. Assessing performance upon abrupt awakening from nap during quasi-continuous operations. Behavior Research Methods. 1985;17:37-45

  RESULT

• Jewett ME, Wyatt JK, Ritz-De Cecco A, Khalsa SB, Dijk DJ, Czeisler CA. Time course of sleep inertia dissipation in human performance and alertness. J Sleep Res. 1999 Mar;8(1):1-8. doi: 10.1111/j.1365-2869.1999.00128.x.

  PMID: 10188130 RESULT

• Tassi P, Muzet A. Sleep inertia. Sleep Med Rev. 2000 Aug;4(4):341-353. doi: 10.1053/smrv.2000.0098.

  PMID: 12531174 RESULT

• Patterson PD, Liszka MK, Mcilvaine QS, Nong L, Weaver MD, Turner RL, Platt TE, Opitz SE, Guyette FX, Martin-Gill C, Weiss LS, Buysse DJ, Callaway CW. Does the evidence support brief (</=30-mins), moderate (31-60-mins), or long duration naps (61+ mins) on the night shift? A systematic review. Sleep Med Rev. 2021 Oct;59:101509. doi: 10.1016/j.smrv.2021.101509. Epub 2021 May 19.

  PMID: 34116386 RESULT

• Lerman SE, Eskin E, Flower DJ, George EC, Gerson B, Hartenbaum N, Hursh SR, Moore-Ede M; American College of Occupational and Environmental Medicine Presidential Task Force on Fatigue Risk Management. Fatigue risk management in the workplace. J Occup Environ Med. 2012 Feb;54(2):231-58. doi: 10.1097/JOM.0b013e318247a3b0. No abstract available.

  PMID: 22269988 RESULT

MeSH Terms

Conditions

Idiopathic Hypersomnia

Condition Hierarchy (Ancestors)

Disorders of Excessive Somnolence; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Central Study Contacts

Pongsakorn Tanayapong, Doctor of Medicine

CONTACT

(66)-64-9626525; pongsakorn.taa@mahidol.ac.th

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 30, 2026
• First Posted: February 13, 2026
• Study Start: February 4, 2026
• Primary Completion: April 15, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: February 13, 2026

Record last verified: 2026-02

Locations

TH (1)