Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic Administration

NCT07409688 | Recruiting Phase 4 DMC

• 1 other identifier: 4726/RTH/RWP
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Laparoscopic cholecystectomy involves removal of gallbladder through small incision ports resulting in faster recovery. Small incisions are less painful and hence local anesthesis administered can be effective for pain management. This local anesthetic can be administered either within abdominal cavity or at sit of small incisions.

Conditions

Laparoscopic Cholecystectomy Surgery; Analgeisa; Local Anesthetic Infiltration

Keywords

Laparoscopic cholecystectomy; Post Operative analgesia; Local anesthetic administration

Outcome Measures

Primary Outcomes (2)

• Post opestive pain score

  This will be measured using Visual Analog score upon arrival at post anesthesia care unit labelled as Time 0 then at time intervals 3h,6h, 12h and 24 hours post operatively

• Rescue analgesia demand

  This will be the number of patients requiring resuce analgesia in 24h post operative period. Rescue analgesia will be administered if VAS score >4

Study Arms (2)

Intraperitoneal local anesthetic administration

EXPERIMENTAL

Drug: Intraoperitoneal local anesthetic administration

Sub cutaneous local anesthetic administration

ACTIVE COMPARATOR

Drug: Sub cutaneous administration of local anesthetic

Interventions

Intraoperitoneal local anesthetic administration DRUG

Intraperitoneal infiltration of 20ml of 0.25% Bupivacaine will be done at the end of procedure by the surgeon.

Intraperitoneal local anesthetic administration

Sub cutaneous administration of local anesthetic DRUG

port site infiltration of 20ml of 0.25% Bupivacaine will be done. 6ml for 10mm ports and 4ml for 5mm ports respectively.

Sub cutaneous local anesthetic administration

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• ASA I and II

You may not qualify if:

• Allergic to local anesthetic Open cholecystectomy History of chronic pain History of abdominal surgery

Sponsors & Collaborators

• Rawalpindi Medical College: lead

Study Sites (1)

Rawalpindi Teaching Hospital, Rawalpindi

Rawalpindi, Punjab Province, Pakistan

RECRUITING

Related Publications (1)

• Bano N, Hayat N, Saleem S, Javaid F, Rehman A, Mudassir. Comparison of intraincisional and intraperitoneal infiltration of local anaesthetic in laparoscopic cholecystectomy to control early postoperative pain. Professional Med J 2021; 28(2):192-196. https://doi.org/10.29309/TPMJ/2021.28.02.6013

  BACKGROUND

Study Officials

• Waqas Anjum

  Rawalpindi Medical College

  STUDY CHAIR

Central Study Contacts

Nimrah Iqbal Prinicpal Investigator, MBBS

CONTACT

+92 335 0526611; drnimrahiqbal@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 19, 2026
• First Posted: February 13, 2026
• Study Start: January 17, 2026
• Primary Completion: June 17, 2026
• Study Completion: June 17, 2026
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)