Multimodal Endoscopic Ultrasound in the Evaluation of Indeterminate Upper Gastrointestinal Wall Thickening

NCT07407296 | Not Yet Recruiting

• 1 other identifier: MM-EUS-UGIWT
• Study Type: observational
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

Multimodal endoscopic ultrasound can help to differentiate between benign (non-cancerous) and malignant (cancerous) causes of thickening of the upper digestive tract wall. The main questions this study aims to answer are: How accurate is multimodal endoscopic ultrasound in identifying the cause of upper digestive tract wall thickening? Can using several ultrasound techniques together improve diagnosis when standard tests are unclear? Participants are adults who have upper digestive tract wall thickening seen on scans such as computed tomography (CT) or magnetic resonance imaging (MRI). Participants will: Undergo upper endoscopy followed by endoscopic ultrasound and tissue sample taken during the procedure when needed followed by using biopsy results or clinical follow-up to confirm the final diagnosis This study aims to improve early and accurate diagnosis and help guide proper treatment decisions for people with unexplained upper digestive tract wall thickening.

Conditions

Upper Gastrointestinal Wall Thickening

Keywords

Endoscopic Ultrasound in Upper Gastrointestinal Wall Thickening

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of multimodal EUS

  one year

Secondary Outcomes (3)

• EUS imaging patterns associated with various etiologies.

  one year

• Incremental diagnostic value of elastography.

  one year

• Diagnostic yield of EUS-guided tissue acquisition.

  one year

Study Arms (1)

Indeterminate Upper Gastrointestinal Wall Thickening

Procedure: Endoscopic ultrasound

Interventions

Endoscopic ultrasound PROCEDURE

Multimodal Endoscopic Ultrasound including; conventional B-mode EUS Assessment, doppler evaluation, EUS elastography and Selective EUS-Guided Fine-Needle Biopsy (EUS-FNB)

Indeterminate Upper Gastrointestinal Wall Thickening

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with endoscopic or radiological (U/S, CT or MRI) evidence of upper GI wall thickening (esophagus, stomach, or duodenum) and defined based on established radiologic standards. A wall thickness by MSCT \>5 mm in the oesophagus and stomach and \>4 mm in the duodenum in accordance with accepted CT imaging criteria

You may qualify if:

• Age ≥18 years
• Patients with endoscopic or radiological (U/S, CT or MRI) evidence of upper GI wall thickening (esophagus, stomach, or duodenum) and defined based on established radiologic standards. A wall thickness by MSCT \>5 mm in the oesophagus and stomach and \>4 mm in the duodenum in accordance with accepted CT imaging criteria (4, 7).
• Written informed consent provided.

You may not qualify if:

• Patient refusal or inability to provide informed consent
• Uncorrectable coagulation disorder e.g prothrombin concentration \<60%, INR \>1.5 or platelet count \<50,000/µL that cannot be corrected pre-procedure according to institutional guidelines.
• Presence of contraindications for endoscopy/sedation.
• Known diagnosis explaining wall thickening prior to EUS.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Egypt, 71515, Egypt

Location

Related Publications (7)

• Desai R, Tagliabue J, Wegryn S, Einstein D. CT evaluation of wall thickening in the alimentary tract. Radiographics. 1991;11(5):771-83.

  RESULT

• Téllez-Ávila F, Duarte-Medrano G, Lopez-Arce G, Herrera-Mora D, Ramírez-Luna M, Valdovinos-Andraca F, et al. EUS-guided tissue samples for the diagnosis of patients with a thickened gastric wall and prior negative endoscopic biopsies. Acta Gastro-Enterologica Belgica. 2019;82.

  RESULT

• Macari M, Balthazar EJ. CT of bowel wall thickening: significance and pitfalls of interpretation. American Journal of Roentgenology. 2001;176(5):1105-16.

  RESULT

• Ergin M, Kıvrakoğlu F. Evaluation of Endoscopic Findings in Gastrointestinal Tract Wall Thickening Detected on kAbdominal Radiological Imaging: A Two-Center Retrospective Descriptive Study. Medicina. 2025;61(9):1699.

  RESULT

• Jung K, Park MI, Kim SE, Park SJ. Borrmann type 4 advanced gastric cancer: focus on the development of scirrhous gastric cancer. Clinical endoscopy. 2016;49(4):336-45.

  RESULT

• Chen T, Wu C, Lee C, Lai Y, Yang S. Endoscopic ultrasonography in the differential diagnosis of giant gastric folds. Journal of the Formosan Medical Association= Taiwan yi zhi. 1999;98(4):261-4.

  RESULT

• Giri S, Narayan J, Angadi S, Shah B, Ingle M, Tyagi U, et al. Role of endoscopic ultrasound-guided tissue acquisition for the diagnosis of gastric wall thickening: a retrospective study with meta-analysis. Annals of Gastroenterology. 2023;36(6):605.

  RESULT

MeSH Terms

Interventions

Endoscopic Ultrasound-Guided Fine Needle Aspiration

Intervention Hierarchy (Ancestors)

Biopsy, Fine-Needle; Biopsy, Needle; Biopsy; Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Image-Guided Biopsy; Specimen Handling; Ultrasonography, Interventional; Ultrasonography; Diagnostic Imaging; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures; Investigative Techniques

Study Officials

• Taha Hussein El-sherif

  Assit University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Taha Hussein El-sherif

CONTACT

00201114236391; Elsheriftaha74@gmail.com

Ahmed Radwan Riad

CONTACT

00201126435001; Dr.Radwan@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistent Lecturer at Tropical Medicine and Gastroenterology

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: February 12, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2028
• Last Updated: February 12, 2026

Record last verified: 2026-02

Locations

EG (1)