Effect of Combined Quadriceps and Calf Strengthening Program on Gait in Knee Osteoarthritis Patients
1 other identifier
interventional
52
1 country
1
Brief Summary
The aim of this study is to determine the effects of a combined quadriceps and calf strengthening program on gait, strength, pain, disability, functional mobility, and sleep quality in patients with knee osteoarthritis. A randomized controlled trial will be conducted at Hayatabad Medical Complex, Peshawar. A total of 52 participants aged 40-60 years with grade 2-3 knee osteoarthritis will be recruited using non-probability convenience sampling and randomly allocated into experimental and control groups. Outcome measures include Kinovea software for gait analysis, hand-held dynamometer for strength, Numeric Rating Scale for pain, WOMAC for disability, Timed Up and Go test for function, and Pittsburgh Sleep Quality Index for sleep quality. Data will be analyzed using SPSS version 27 employing repeated measures ANOVA and mixed-way ANOVA.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable knee-osteoarthritis
Started Feb 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2026
CompletedFirst Submitted
Initial submission to the registry
February 4, 2026
CompletedFirst Posted
Study publicly available on registry
February 11, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 31, 2027
February 11, 2026
February 1, 2026
11 months
February 4, 2026
February 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Temporo-spatial Gait
Gait parameters will be measured by Kinovea Software.A video of the gait will be recorded and then evaluated with kinovea.
from baseline to 6 weeks
Quadriceps Strength
the Hand Held Dynamometer will be used to asses the strength of quadriceps
from baseline to 6 weeks
Calf Strength
the Hand Held Dynamometer will be used to asses the strength of Calf
from baseline to 6 weeks
Secondary Outcomes (4)
Knee Pain
from baseline to 6 weeks
knee Disability
from baseline to 6 weeks
knee Function
from baseline to 6 weeks
Sleep Quality
from baseline to 6 weeks
Study Arms (2)
Group A (Combined Quadriceps and Calf Strengthening)
EXPERIMENTALThe experimental group will receive physiotherapy treatment consisting of the application of a heating pad for 10 minutes, followed by Grade II joint mobilization, quadriceps strengthening exercises, and calf strengthening exercises
Group B (Conventional)
ACTIVE COMPARATORThe control group will receive conventional physiotherapy treatment, which included the application of a heating pad for 10 minutes, followed by Grade II joint mobilization, and quadriceps strengthening exercises.
Interventions
During weeks 1-2, Group A will receive a heating pad for 10 minutes followed by Grade II joint mobilization. This will be followed by strengthening exercises including quadriceps strengthening in the form of straight leg raises, quadriceps sets, and leg extension exercises with 1 kg weight. Calf strengthening exercises will also be performed, including standing heel raises, seated calf raises, and standing single heel raises with support. All exercises will be initially performed with 10 repetitions and 1 set. During weeks 3-4, the exercise protocol will progress by increasing the repetitions to 12, sets to 2, and external resistance to 1.5 kg. During weeks 5-6, further progression will be made by increasing the repetitions to 15, sets to 3, and external resistance to 2 kg.
During weeks 1-2, Group B will receive a heating pad for 10 minutes followed by Grade II joint mobilization. This will be followed by quadriceps strengthening in the form of straight leg raises, quadriceps sets, and leg extension exercises with 1 kg weight. All exercises will be initially performed with 10 repetitions and 1 set. During weeks 3-4, the exercise protocol will progress by increasing the repetitions to 12, sets to 2, and external resistance to 1.5 kg. During weeks 5-6, further progression will be made by increasing the repetitions to 15, sets to 3, and external resistance to 2 kg.
Eligibility Criteria
You may qualify if:
- Both Male and Female
- Participants aged 40-60years.
- Diagnosed with grade 2 and 3 of knee osteoarthritis according to Kellgren-Lawrence
- Quads manual muscle grading \<4
- Ability to understand and comply with exercise instructions.
You may not qualify if:
- History of recent knee surgery or trauma in the past six months.
- Inflammatory joint diseases (e.g., rheumatoid arthritis, gout).
- Severe cardiovascular or neurological disorders.
- Uncontrolled hypertension or diabetes.
- Participation in other physiotherapy or pharmacological interventions for knee OA during the study period.
- Cognitive impairment or inability to follow commands
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hayatabad Medical Complex
Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Aisha Razzaq, PHD
Riphah International University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 4, 2026
First Posted
February 11, 2026
Study Start
February 1, 2026
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
January 31, 2027
Last Updated
February 11, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share