Effects of Protective Step Training on Proactive and Reactive Motor Adaptations in Parkinson's Disease Patients

NCT07399613 | Completed DMC

• 1 other identifier: STUDY00015237
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate to what extent PD affects the ability to walk, respond to balance perturbations (i.e., Protective Step Training) and produce acute short-term effects to improve compensatory reactions and control of unperturbed walking balance.

Conditions

Fall; Protective Step Training; Falls, Intervention; Fall Prevention Training; Accidental Falls; Parkinson Disease

Keywords

Parkinson Disease, Falls, intervention, training, Protective Step Training, accidental falls

Outcome Measures

Primary Outcomes (1)

• Joint (knee) reaction time

  Joint (knee) Reaction time during standing and walking perturbations.

  one year

Study Arms (2)

Standing Perturbation Protocol

EXPERIMENTAL

Different postural perturbations were administered - while walking and while standing.

Behavioral: Protective Step Training

Walking Perturbation Protocol

EXPERIMENTAL

Different postural perturbations were administered - while walking and while standing.

Behavioral: Protective Step Training

Interventions

Protective Step Training BEHAVIORAL

Perturbation during standing and walking to actively assess proactive as well as reactive motor adaptations.

Also known as: perturbation training, reactive step training

Standing Perturbation Protocol; Walking Perturbation Protocol

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• able to ambulate without assistance
• had no known neurologic, cardiovascular, or orthopedic deficit - (Mini-Mental Status Examination \<25), and had a Hoehn \& Yahr (H\&Y) score between II-III.

You may not qualify if:

• exhibited functionally disabling dyskinesia
• has dystonia, orthostatic hypotension,
• had neurosurgical intervention (deep brain stimulation)
• has and any significant musculoskeletal or metabolic disorders.

Sponsors & Collaborators

• Arizona State University: lead
• U.S. National Science Foundation: collaborator

Study Sites (1)

Glencroft Senior Living: Retirement Community in Arizona

Glendale, Arizona, 85302, United States

Location

Related Publications (1)

• Lockhart T, Frames C, Olson M, Moon SH, Peterson D, Lieberman A. Effects of protective step training on proactive and reactive motor adaptations in Parkinson's disease patients. Front Neurol. 2023 Oct 24;14:1211441. doi: 10.3389/fneur.2023.1211441. eCollection 2023.

  PMID: 37965161 RESULT

Related Links

• Frontiers Journal Manuscript

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Randomized the all walking/training trials
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Crossover design: Prior to testing, subjects were randomly assigned to two groups. One group started with postural perturbation (PP) training (during stance), while the other group began with gait perturbation (GP) training before crossing over (during walking). During this onboarding period, self-reported and observed leg dominance in bilateral mobilizing was utilized to determine the dominant leg that will be perturbed in the walking trials. Investigators described a scenario for the participant in which they were asked which leg they would use to kick a ball over the ground.

Study Record Dates

• First Submitted: December 12, 2024
• First Posted: February 10, 2026
• Study Start: January 19, 2022
• Primary Completion: January 18, 2023
• Study Completion: March 18, 2023
• Last Updated: February 10, 2026

Record last verified: 2025-05

Locations

US (1)