NCT07398430

Brief Summary

Obstructive sleep apnea (OSA) significantly increases the risk of cardiovascular events in patients with acute coronary syndrome (ACS), yet the underlying metabolic mechanisms remain unclear. This study aims to analyze the metabolic characteristics of ACS patients with OSA using metabolomics based on a prospective cohort. The study intends to construct an artificial intelligence-based risk stratification model to improve prognosis prediction and facilitate precision medicine for this population.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for all trials

Timeline
19mo left

Started Feb 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress19%
Feb 2026Dec 2027

Study Start

First participant enrolled

February 1, 2026

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

February 4, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

February 9, 2026

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

February 9, 2026

Status Verified

February 1, 2026

Enrollment Period

1.9 years

First QC Date

February 4, 2026

Last Update Submit

February 4, 2026

Conditions

Sleep Disordered Breathing (SDB)

Outcome Measures

Primary Outcomes (1)

  • Incidence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)

    12 Months

Interventions

Biological Sample CollectionOTHER

Collection of blood, urine, and stool samples for metabolomics analysis.

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Hospitalized patients diagnosed with ACS at Beijing Hospital.

You may qualify if:

  • Age 18-85 years.
  • Diagnosed with ACS, including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina.
  • Willing to participate and sign the informed consent form.

You may not qualify if:

  • Cardiogenic shock or cardiac arrest.
  • Central sleep apnea or other types of sleep disordered breathing.
  • Previous or current treatment with continuous positive airway pressure.
  • Inability to complete polysomnography or invalid data.
  • Malignancy or life expectancy \< 1 year.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

ApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Central Study Contacts

Wei Gong

CONTACT

+86 13717676086gongwei5180@bjhmoh.cn

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
12 Months
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Deputy Director

Study Record Dates

First Submitted

February 4, 2026

First Posted

February 9, 2026

Study Start

February 1, 2026

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

February 9, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share