Necessity of Post-operative Eye Drops

NCT07396831 | Terminated

• 1 other identifier: 5230480
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical study is to determine if antibiotic eye drops are needed after retinal surgery to prevent infection. Currently, patients are prescribed antibiotic eye drops to use for several weeks after they undergo retina surgery. The main question that we are trying to answer is: \- Are postoperative eye drops necessary to prevent eye infections after retina surgery? Patients will still receive steroid drops after their surgery to control inflammation. Additionally, patients will have regular follow up with their eye surgeon to monitor for the signs and symptoms of eye infection.

Conditions

Pars Plana Vitrectomy; Scleral Buckling; Surgical Outcomes; Infection Prophylaxis

Keywords

Pars plana vitrectomy; Scleral buckling; Infection prophylaxis; Topical antibiotics

Outcome Measures

Primary Outcomes (1)

• Presence of endophthalmitis

  The primary outcome of this study is the presence of endophthalmitis 30 days after pars plana vitrectomy and/or scleral buckling without the use of post-operative antibiotics.

  30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients from a single vitreoretinal surgeon at Loma Linda University Medical Center.

You may qualify if:

• Patients undergoing Pars plana vitrectomy and/or scleral buckling

You may not qualify if:

• Patients younger than 18
• Patients undergoing Pars plana vitrectomy for endophthalmitis
• Patients having combined intraocular lens and vitrectomy surgery
• Patients that received a cornea scrape during surgery

Sponsors & Collaborators

• Loma Linda University: lead

Study Sites (1)

Loma Linda University Eye Institute

Loma Linda, California, 92354, United States

Location

Related Publications (1)

• Dave VP, Pathengay A, Schwartz SG, Flynn HW Jr. Endophthalmitis following pars plana vitrectomy: a literature review of incidence, causative organisms, and treatment outcomes. Clin Ophthalmol. 2014 Oct 31;8:2183-8. doi: 10.2147/OPTH.S71293. eCollection 2014.

  PMID: 25382968 BACKGROUND

Study Officials

• Bailey Shen, Doctor of Medicine

  Loma Linda University Eye Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 2, 2026
• First Posted: February 9, 2026
• Study Start: April 9, 2024
• Primary Completion: December 22, 2025
• Study Completion: December 22, 2025
• Last Updated: February 9, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share

Locations

US (1)