Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder

NCT07395453 | Not Yet Recruiting

• 1 other identifier: OCD in substances use disorder
• Study Type: observational
• Target: 102
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder. Patients aged 18-50 years attending the addiction management inpatient and outpatient services at Assiut University Hospital, and healthy controls recruited from relatives, friends, and hospital staff, will complete structured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale, and other standardized scales for psychiatric symptoms, cognition, and quality of life. The main objective is to estimate the prevalence and severity of obsessive-compulsive symptoms in substance use disorder and examine their associations with sociodemographic and clinical factors, addiction severity, and quality of life in the recovery stage.

Conditions

Obsessive - Compulsive Disorder; Obsessive Compulsive Disorder (OCD); Obsessive Compulsive Behavior; Substance Abuse Disorder; Substance Use

Keywords

obsessive-compulsive symptoms; substances use disorder

Outcome Measures

Primary Outcomes (1)

• Severity of Obsessive-Compulsive Symptoms in Patients with Substance Use Disorder Measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Total Score

  Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score assessing severity of obsessive-compulsive symptoms in patients with substance use disorder. Scale ranges from 0 to 40 points, where higher scores indicate greater severity, assessed once at study enrollment during recovery stage defined as non-intoxication and non-withdrawal.

  Baseline (study enrollment during recovery stage defined as non-intoxication and non-withdrawal); single assessment

Study Arms (2)

Substance Use Disorder Patients

Adults aged 18-50 years with a diagnosed substance use disorder (single or polysubstance) attending the inpatient or outpatient addiction management unit at Assiut University Hospital, assessed for obsessive-compulsive symptoms, psychiatric comorbidities, cognition, and quality of life using standardized scales and urine toxicology.

Healthy Control Group

Adults aged 18-50 years without substance use disorder, recruited from relatives, friends, or hospital workers, matched on sociodemographic characteristics where feasible, and assessed with the same clinical and psychometric battery to compare obsessive-compulsive symptoms and related outcomes with the patient group.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18-50 years attending the inpatient and outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital, with a diagnosed substance use disorder, and a comparison group of relatives, friends, or hospital workers without substance use disorder. Participants of both sexes who provide informed consent will be assessed once during the recovery (non-intoxication, non-withdrawal) stage using structured clinical interviews, standardized scales for obsessive-compulsive symptoms, psychiatric comorbidity, cognition, and global psychopathology, as well as urine toxicology.

You may qualify if:

• Adults aged 18-50 years.
• Willing and able to provide informed consent and participate in the study assessments.
• For the case group: patients with a diagnosed substance use disorder (single or polysubstance) attending the inpatient or outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital.
• For the control group: relatives, friends, or hospital workers without substance use disorder, recruited through invitation or advertisement.

You may not qualify if:

• Severe psychiatric comorbidities such as schizophrenia, major depressive disorder, bipolar disorder, or anorexia nervosa.
• Current intoxication or acute withdrawal state from substances.
• Severe medical conditions including end-stage renal disease, metastatic cancer, severe heart failure, or chronic obstructive pulmonary disease.
• Severe cognitive impairment

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Compulsive Personality Disorder; Obsessive-Compulsive Disorder; Compulsive Behavior; Substance-Related Disorders

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Anxiety Disorders; Impulsive Behavior; Behavior; Chemically-Induced Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Neurology and Psychiatry

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: February 9, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: February 9, 2026

Record last verified: 2026-02