Guided Bone Regeneration Using Ti-Reinforced PTFE Membrane Vs. Khoury's Technique in Augmentation of Posterior Mandibular Defects

NCT07394933 | Active Not Recruiting DMC

• 1 other identifier: 25-019
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present clinical trial is to compare two different alveolar ridge bone augmentation techniques for mandibular horizontal bone defects.

Conditions

Atrophic Ridge

Outcome Measures

Primary Outcomes (1)

• Cone Beam Volumetric Topography (CBVT)

  6 Months

Secondary Outcomes (1)

• Clinical measurement: the frequency of complications

  6 Months

Study Arms (2)

Khoury's bone shell technique

ACTIVE COMPARATOR

Bone blocks will be harvested from the retromolar area after measuring of the size required and measuring of the donor site anatomy. Piezoelectric device will be used to perform the graft osteotomy. The block size should be slightly larger than the defect size. Sharp bony edges will be smoothened, and the donor defect will be packed with gelatin sponges. The bone block margins will be smoothened and separated into two thinner bone shells using titanium disk with copious saline irrigation. The blocks will be fixed into the recipient site buccally using at least two micro-screws leaving a gap to be filled with bone graft.

Procedure: Khoury's bone shell technique

GBR using Ti-reinforced PTFE Membrane

EXPERIMENTAL

A non-resorbable ti-enforced polytetrafluoroethylene (PTFE) membrane will be fixed with titanium screws on the lingual bone plate and on the buccal bone plate allowing for packing of particulate mix of bone graft (50% Xenograft: 50% Autogenous graft).

Procedure: GBR using Ti-reinforced PTFE Membrane

Interventions

Khoury's bone shell technique PROCEDURE

Bone blocks will be harvested from the retromolar area after measuring of the size required and measuring of the donor site anatomy. Piezoelectric device will be used to perform the graft osteotomy. The block size should be slightly larger than the defect size. Sharp bony edges will be smoothened, and the donor defect will be packed with gelatin sponges. The bone block margins will be smoothened and separated into two thinner bone shells using titanium disk with copious saline irrigation. The blocks will be fixed into the recipient site buccally using at least two micro-screws leaving a gap to be filled with bone graft.

Khoury's bone shell technique

GBR using Ti-reinforced PTFE Membrane PROCEDURE

A non-resorbable ti-enforced polytetrafluoroethylene (PTFE) membrane will be fixed with titanium screws on the lingual bone plate and on the buccal bone plate allowing for packing of particulate mix of bone graft (50% Xenograft: 50% Autogenous graft).

GBR using Ti-reinforced PTFE Membrane

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Have one or more missing teeth in the posterior mandibular segment.
• The alveolar ridge in the edentulous site of the selected patients will have a buccolingual width of less than 5 mm.
• Sufficient vertical bone height above inferior alveolar nerve.
• Free of any local or systemic condition that may contraindicate ridge expansion procedure.
• No sex predilection.
• The patient will be between the ages of 18-70 years.

You may not qualify if:

• Patients taking any medication that may interfere with bone healing or bone biology.
• Patients with any systemic disease that may affect bone healing.
• Any patients with any previous bone grafting procedure at the site of interest.
• Heavy Smokers (more than 20 cigarettes daily).
• Patient's that have been diagnosed with periodontal disease, as sufficient ridge height would be improbable.

Sponsors & Collaborators

• British University In Egypt: lead

Study Sites (1)

Faculty of Dentistry - The British University in Egypt

Cairo, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 31, 2026
• First Posted: February 6, 2026
• Study Start: June 15, 2025
• Primary Completion: October 15, 2025
• Study Completion: April 1, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Locations

EG (1)