Does Early Postoperative Fluid Management Affect Functional Delayed Graft Function After Living Donor Kidney Transplantation?

NCT07392996 | Active Not Recruiting

• 1 other identifier: RENALTRANSAÜTF
• Study Type: observational
• Target: 122
• Locations: 1 country
• Sites: 1

Brief Summary

Fluid management in renal transplantation is of critical importance for optimizing graft function and minimizing complications such as delayed graft function (DGF) and acute kidney injury (AKI). The aim of this study was to retrospectively investigate the effects of early postoperative (the first 4 hours after transplantation) fluid replacement volume on graft function in patients undergoing living donor kidney transplantation.

Conditions

Renal Transplant; DGF

Keywords

Kidney transplantation; fDGF; fluid replacement; living organ donor

Outcome Measures

Primary Outcomes (1)

• Functional Delayed Graft Function (fDGF)

  Functional delayed graft function (fDGF) was defined as the absence of a spontaneous daily decrease of at least 10% in serum creatinine levels for three consecutive days during the first postoperative week. To avoid misclassification in patients with excellent early graft function, a lack of creatinine decline on postoperative day 3 was not classified as fDGF if optimal graft function had already been achieved by postoperative day 2.

  postoperatif 7 days

Secondary Outcomes (1)

• Kidney transplant function

  Postoperative 1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Between 2017 and 2025, 122 patients who met the inclusion criteria for the study were enrolled from among recipients and donors of living donor renal transplants performed in the General Surgery operating theatre at Ankara University İbni Sina Research and Application Hospital.

You may qualify if:

• Renal transplant recipients and donors aged 18 years and older
• Renal transplant from a living donor

You may not qualify if:

• Patients under 18 years of age
• Patients with incomplete or missing medical records
• Patients with heart disease (ejection fraction \< 30)
• Multiple organ transplant
• History of repeated kidney transplants
• Cadaveric renal transplant

Sponsors & Collaborators

• Ankara University: lead

Study Sites (1)

Ankara University İbni Sina Research and Application Hospital

Ankara, Çankaya, Turkey (Türkiye)

Location

Study Officials

• Süheyla Karadağ Erkoç

  Ankara University İbni Sina Research and Application Hospital.

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 16, 2026
• First Posted: February 6, 2026
• Study Start: September 1, 2025
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: February 12, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)