Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
Postoperative Delayed Neurocognitive Recovery in Elderly Patients Undergoing Spinal Anesthesia: Assessment of Its Prevalence and Correlation With Preoperative Sleep Disorders and Melanin Concentrating Hormone.
1 other identifier
observational
50
0 countries
N/A
Brief Summary
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal anesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 31, 2026
CompletedStudy Start
First participant enrolled
February 1, 2026
CompletedFirst Posted
Study publicly available on registry
February 6, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2027
February 10, 2026
January 1, 2026
1 year
January 31, 2026
February 6, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
To investigate the impact of preoperative sleep problems as indicators of delayed neurocognitive recovery (DNR) in elderly adults following spinal anesthesia.
By comparison between the two groups
Baseline, one week, three months
Secondary Outcomes (1)
to investigate the predictive power of CSF and plasma MCH levels for delayed neurocognitive recovery (DNR) in older adults after spinal anesthesia
Baseline one day before operation
Study Arms (2)
Group A
25 patients with preoperative sleep disorders
Group B
25 patients without preoperative sleep disorders
Eligibility Criteria
A total of (50) patients candidate for elective lower limb surgery aged from 65 years of both sexes will be enrolled in this study.
You may qualify if:
- Patients of both genders ageing 65 years or above.
- ASA grade I to III.
- Undergo elective lower limb surgery under spinal anesthesia
- Agree to collect one's own CSF and blood samples
You may not qualify if:
- Past history of depression,anxiety,delirium and schizophrenia .
- Past history of drug dependence.
- Past history of dementia,including Alzheimer disease(AD).
- Preoperative Montreal Cognitive Assessment (MoCA) score \<26.
- Inability to understand or cooperate with the evaluation scale or questionnaire.
- Refuse collecting one's own CSF and blood samples.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Minia Universitylead
Related Publications (9)
Wagner S, Ahrens E, Wachtendorf LJ, et al. Association of obstructive sleep apnea with postoperative delirium in procedures of moderate-to-high complexity: a hospital-registry study. Anesth Analg. 2023.
BACKGROUNDTravica N, Lotfaliany M, Marriott A, et al. Peri-operative risk factors associated with post-operative cognitive dysfunction (POCD): an umbrella review of meta-analyses of observational studies. J Clin Med. 2023;12:1610.
BACKGROUNDPOIRIER, Gabriel, et al. Deterioration, compensation and motor control processes in healthy aging, mild cognitive impairment and Alzheimer's disease. Geriatrics, 2021, 6.1: 33
BACKGROUNDMonti JM, Torterolo P, Lagos P. Melanin-concentrating hormone control of sleep-wake behavior. Sleep Med Rev.2013;17:293-298. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699.
BACKGROUNDLi Yun,Zhang Xizhe, et al . Research progress on the role of melanin-concentrating hormone system in sleep deprivation -induced impairment of learning and memory function [ J ] . International Journal of Anesthesiology and Resuscitation , 2022 , 43 ( 10 ): 1117-1120 .
BACKGROUNDBuysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res.1989;28:193-213.
BACKGROUNDButris N, Tang E, Pivetta B, et al. The prevalence and risk factors of sleep disturbances in surgical patients:a systematic review and meta-analysis. Sleep Med Rev.2023;69:101786.
BACKGROUNDNasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699.
BACKGROUNDMonti JM, Torterolo P, Lagos P. Melanin-concentrating hormone control of sleep-wake behavior. Sleep Med Rev.2013;17:293-298.
BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mohamed Mostafa Ali, MD
El-minya University Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator, assistant lecturer anesthesiologist
Study Record Dates
First Submitted
January 31, 2026
First Posted
February 6, 2026
Study Start
February 1, 2026
Primary Completion (Estimated)
February 1, 2027
Study Completion (Estimated)
April 1, 2027
Last Updated
February 10, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will not share