Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy

NCT07388797 | Not Yet Recruiting

• 1 other identifier: 2025.875
• Study Type: observational
• Target: 370
• Locations: 1 country
• Sites: 1

Brief Summary

Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT). Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer Secondary outcomes: Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.

Conditions

Reproductive Issues

Outcome Measures

Primary Outcomes (1)

• Clinical pregnancy rate (CPR)

  Rate of clinical pregnancy outcome in subjects undergoing FET

  6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET

Secondary Outcomes (4)

• Biochemical pregnancy rate

  Up to 12 weeks

• Implantation rate

  Up to 12 weeks

• Early pregnancy loss rate

  Up to 12 weeks

• Ectopic pregnancy rate

  Up to 12 weeks

Eligibility Criteria

• Age: 18 Years - 42 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All infertility patients undergoing FET at the Assisted Reproductive Technology Unit of the department of Obstetrics and Gynecology in the Prince of Wales Hospital

You may qualify if:

• Patients undergoing FET cycles
• Infertility patients aged \>18 years old and \< 42 years old
• BMI \< 30 kg/m2
• Transfer of at least one good-quality embryo.

You may not qualify if:

• Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
• Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, China

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 29, 2026
• First Posted: February 5, 2026
• Study Start: February 10, 2026
• Primary Completion (Estimated): June 30, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: February 11, 2026

Record last verified: 2026-02

Locations

CN (1)