Exercise Therapy for Multiple Myeloma Patients

NCT07388147 | Not Yet Recruiting

• 1 other identifier: S-561/2025
• Study Type: interventional
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

Physical exercise is an important supportive therapy for cancer patients, as it improves quality of life in general and might mitigate the side effects of drug treatment. For patients with multiple myeloma in particular, significantly less evidence on the effectiveness of exercise therapy is available due to the fact that this disease is associated with severe bone degradation which might affect bone stability. Advances in oncologic drug treatment have improved overall survival in multiple myeloma significantly. Therefore, there is an increased interest for recommendations on physical activity in this patient group. Due to uncertainties regarding safety and feasibility of exercise therapy in multiple myeloma, both patients and therapists often remain hesitant. Therefore, an orthopaedic outpatient clinic has been established at the Myeloma Center of Heidelberg University Hospital. Here, patients receive consultation on bone stability and individualized physical exercise plans. Based on the expertise gained at the orthopaedic outpatient clinic, the aim of this study is to establish and evaluate structural measures for improved rehabilitation in multiple myeloma and to integrate them into routine clinical care.

Conditions

Multiple Myeloma Bone Lesions

Keywords

Implementation of structural measures; Rehabilitation; Exercise therapy; Multiple Myeloma; Bone lesions

Outcome Measures

Primary Outcomes (1)

• Change in physical function

  Results of the EORTC QLQ-C30 questionnaire ("Physical functioning" scale)

  From enrollment to the end of induction therapy after 18 weeks

Study Arms (1)

Orthopedic consultation and exercise to evaluate structural measures and improve rehabilitation

ACTIVE COMPARATOR

Other: Orthopedic consultation and rehabilitation by excercise therapy

Interventions

Orthopedic consultation and rehabilitation by excercise therapy OTHER

All patients will receive a continuous orthopaedic consultation on bone stability and recommendations for exercise therapy during the different phases of systemic myeloma therapy. Thereby, structural measures to improve rehabilitation in multiple myeloma will be established and evaluated with the intention of integrating them into routine clinical care.

Orthopedic consultation and exercise to evaluate structural measures and improve rehabilitation

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• newly diagnosed multiple myeloma
• Survival prognosis \> 6 months
• ECOG status ≤ 3
• Age ≥18 years
• Patients who state that they want to carry out the training program at least 2 x/week and participate in the planned follow-up visits
• Ability to give informed consent
• Written consent to participate in the study
• Sufficient knowledge of written and spoken German

You may not qualify if:

• physical or mental limitation that would prevent participation in the training program or the planned follow-up visits

Sponsors & Collaborators

• University Hospital Heidelberg: lead

Study Sites (1)

Heidelberg University Hospital - GMMG Study Group

Heidelberg, 69120, Germany

Location

MeSH Terms

Conditions

Multiple Myeloma

Condition Hierarchy (Ancestors)

Neoplasms, Plasma Cell; Neoplasms by Histologic Type; Neoplasms; Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Paraproteinemias; Blood Protein Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemorrhagic Disorders; Lymphoproliferative Disorders; Immunoproliferative Disorders; Immune System Diseases

Central Study Contacts

Ulrike Dapunt

CONTACT

06221 56 32765; ulrike.dapunt@med.uni-heidelberg.de

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. med.

Study Record Dates

• First Submitted: January 19, 2026
• First Posted: February 4, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 31, 2029
• Study Completion (Estimated): March 31, 2029
• Last Updated: February 4, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share

Locations

DE (1)