Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment

NCT07386678 | Not Yet Recruiting

• 1 other identifier: EDGE 179423
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR) Purpose and nature of the study:

1. 1.Characterise the cytokine profile of vitreous fluid in uncomplicated RRD.
2. 2.Develop a risk model to predict development of PVR after retinal detachment surgery using imaging and molecular biomarkers.
3. 3.To develop deep learning/artificial intelligence (AI) models for PVR detection in retinal detachment.

Conditions

Proliferative Vitreoretinopathy; Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment; Retinal Detachment Rhegmatogenous

Keywords

Cytokines; Imaging

Outcome Measures

Primary Outcomes (1)

• Characterise the cytokine milieu in an uncomplicated RRD eye.

  Study cytokine profile using a multiplex assay that includes all relevant cytokines.

  3 months

Secondary Outcomes (2)

• Develop a risk model for development of PVR after retinal detachment surgery using imaging and molecular biomarkers.

  3 months

• To develop deep learning AI models for PVR detection in retinal detachment.

  3 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Adults ≥18 years * Uncomplicated primary rhegmatogenous retinal detachment * Moorfields Eye Hospital

You may qualify if:

• Adults ≥18 years
• Uncomplicated primary rhegmatogenous retinal detachment
• PVD present
• No PVR-A/B/C
• Phakic or pseudophakic.

You may not qualify if:

• Patients \<18 years
• Patients lacking capacity
• Previous vitrectomy
• Previous cryopexy
• Aphakia
• No fundal view
• Diabetic retinopathy of any severity
• Retinal detachment secondary to infective causes e.g. acute retinal necrosis, toxoplasmosis scars
• Retinal detachment secondary to congenital defects e.g. optic disc pit/coloboma
• Exudative retinal detachment
• Tractional retinal detachment
• Ongoing involvement in another ocular trial.

Sponsors & Collaborators

• University College, London: lead

Study Sites (1)

Moorfields Eye Hospital

London, N17 9GZ, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Vitreous

MeSH Terms

Conditions

Vitreoretinopathy, Proliferative

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 4, 2026
• Study Start: April 27, 2026
• Primary Completion (Estimated): January 27, 2027
• Study Completion (Estimated): January 27, 2027
• Last Updated: May 6, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF

Locations

GB (1)