NCT07386197

Brief Summary

Postoperative pain is an important consideration in endodontic treatment, and its incidence may be influenced by both obturation technique and sealer type. This study focused on molars to minimize anatomical variability and provide a consistent assessment of pain associated with different endodontic protocols. This study aimed to evaluate the incidence and level of postoperative pain in molars treated with root canal therapy, in relation to the type of sealer and obturation technique used.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 7, 2022

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 28, 2023

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 2, 2023

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

January 15, 2026

Completed
20 days until next milestone

First Posted

Study publicly available on registry

February 4, 2026

Completed
Last Updated

February 4, 2026

Status Verified

January 1, 2026

Enrollment Period

10 months

First QC Date

January 15, 2026

Last Update Submit

January 27, 2026

Conditions

Dental Pulp Necrosis

Keywords

Root canal treatmentObturationSealerPostoperative pain

Outcome Measures

Primary Outcomes (1)

  • Pain level after obturation of root canals

    The level of pain the patient will experience after obturation of the teeth using a visual analogue scale and a numerical scale from 0-10. Zero is the minimum and 10 is the maximum. The higher the score the worse it is, the best technique will have low scores of pain

    6 hours, 1 day, 2 days, 3 days and 1 week

Study Arms (4)

AH Plus resin sealer with cold lateral compaction

ACTIVE COMPARATOR

Obturation using cold lateral condensation and resin sealer

Procedure: Obturation of root canals

AH Plus with warm vertical compaction

ACTIVE COMPARATOR

Obturation using warm vertical compaction and resin sealer

Procedure: Obturation of root canals

TotalFill bioceramic sealer with single-cone technique

ACTIVE COMPARATOR

Obturation with single cone and bioceramic sealer

Procedure: Obturation of root canals

TotalFill HiFlow with warm vertical compaction

ACTIVE COMPARATOR

Obturation with warm vertical compaction and bioceramic sealer

Procedure: Obturation of root canals

Interventions

Obturation of root canalsPROCEDURE

filling of root canal using different materials of resin based or bioceramic based and cold lateral condensation or warm vertical condenstion techniques

Also known as: Root canal filling with bioceramic sealers
AH Plus resin sealer with cold lateral compactionAH Plus with warm vertical compactionTotalFill HiFlow with warm vertical compactionTotalFill bioceramic sealer with single-cone technique

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • both male and female patients within
  • The age of 18-60 years old who required root canal treatment
  • Either mandibular or maxillary molars with the diagnosis of either; necrotic pulp with asymptomatic apical periodontitis,
  • Teeth with pulp extirpated ( previously initiated root canal treatment) regardless of the periapical status

You may not qualify if:

  • Teeth diagnosed with irreversible pulpitis;
  • Teeth with intracanal abberations or mishaps such as perforations, transportation, severe ledging , broken instruments, apical resorption or open apices;
  • Teeth requiring posts;
  • Any patient on long term steroid or any other medical condition that requires long term analgesic.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jordan university of Science and Technology

Irbid, 221000, Jordan

Location

MeSH Terms

Conditions

Dental Pulp NecrosisBites and StingsPain, Postoperative

Interventions

Root Canal Obturation

Condition Hierarchy (Ancestors)

Dental Pulp DiseasesTooth DiseasesStomatognathic DiseasesNecrosisPathologic ProcessesPathological Conditions, Signs and SymptomsPoisoningChemically-Induced DisordersWounds and InjuriesPostoperative ComplicationsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

Root Canal TherapyEndodonticsDentistry

Study Officials

  • Ahmad Alhiyasat, PhD

    Jordan University of Science and Technology

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Masking Details
The patient is blinded to the type of treatment, the operator is partly blinded until the stage of filling material placement since blinding at this point is not possible due to material differences
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Patients will be randomly assigned into four treatment methods
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 15, 2026

First Posted

February 4, 2026

Study Start

October 7, 2022

Primary Completion

July 28, 2023

Study Completion

October 2, 2023

Last Updated

February 4, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will share

Data will be shared upon reasonable request from the study principal

Shared Documents
STUDY PROTOCOL
Time Frame
After publication of the data and up to 5 years
Access Criteria
Request via email to the study chair
More information

Locations

JO(1)