Frequency and Voluntary Contraction-Dependent Activation of Tonic Vibration Reflex and Bone Myoregulation Reflex

NCT07386145 | Completed

• 1 other identifier: ND 2025-79
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

When vibration is applied, sensors inside the muscle send signals to the nervous system, leading to automatic muscle activation. In this research, vibration will be applied using different body postures (such as standing or semi-squatting) and different vibration frequencies to understand how body position and vibration intensity influence muscle responses. Muscle activity will be recorded using surface electrodes placed on the skin. All procedures are non-invasive, painless, and do not involve medication or surgery. The goal of this study is to improve understanding of how whole-body vibration affects muscle and nerve function. The findings may contribute to future rehabilitation strategies

Conditions

Whole Body Vibration

Keywords

whole-body vibration; bone myoregulation reflex; tonic vibration reflex; muscle spindle; osteocyte; vibration; reflex latency

Outcome Measures

Primary Outcomes (1)

• Latency of the soleus reflex during whole-body vibration

  The primary outcome measure is the latency of the soleus reflex activated by whole-body vibration (WBV). Reflex latency will be calculated using a cumulative averaging method. The vibration stimulus will be recorded via an accelerometer mounted on the vibration platform (LIS344ALH; ±6 g; ECOPACK®, Mansfield, TX, USA). The onset of the mechanical stimulus and the onset of the reflex response will be identified using cumulative averaging. Reflex latency will be defined as the time interval between the onset of the mechanical stimulus and the onset of the reflex response detected on surface electromyography (EMG), and will be expressed in milliseconds (ms).

  Day 1 (During a single experimental session)

Study Arms (4)

Low-Frequency WBV - Upright Posture

EXPERIMENTAL

Participants will receive whole-body vibration at low frequencies (30, 32, 34, 36 Hz) while standing in an upright posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration.

Device: whole-body vibration

Low-Frequency WBV - Semi-Squat Posture

EXPERIMENTAL

Participants will receive whole-body vibration at low frequencies while maintaining a semi-squat posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration.

Device: whole-body vibration

High-Frequency WBV - Upright Posture

EXPERIMENTAL

Participants receive whole-body vibration at high frequency (40, 42, 44, 46 Hz) in an upright posture. Vibration will be applied in 15-second bouts with rest intervals.Soleus muscle activity will be recorded using surface electromyography during vibration.

Device: whole-body vibration

High-Frequency WBV - Semi-Squat Posture

EXPERIMENTAL

Participants will receive whole-body vibration at high frequencies while standing in a semi-squat posture. Each vibration exposure will last 15 seconds, with rest intervals between trials. Soleus muscle activity will be recorded using surface electromyography during vibration.

Device: whole-body vibration

Interventions

whole-body vibration DEVICE

Participants will receive whole-body vibration using a vibration platform under different frequency and posture conditions. Vibration will be applied in short bouts (e.g., 15 seconds per trial) with rest periods between trials to minimize fatigue. Reflex and muscle activity responses will be recorded during vibration using surface electromyography (EMG)

High-Frequency WBV - Semi-Squat Posture; High-Frequency WBV - Upright Posture; Low-Frequency WBV - Semi-Squat Posture; Low-Frequency WBV - Upright Posture

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being between 20-40 years old
• Volunteering to participate in the research

You may not qualify if:

• Refusal to participate in the study
• Intolerance to whole-body vibration (WBV)
• History of vertigo
• Presence of malignant disease
• Presence of chronic systemic disease
• Pregnancy

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Therapy and Rehabilitation Training Research Hospital

Istanbul, Bahcelievler, 34180, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This is a crossover interventional study in which each participant is exposed to multiple whole-body vibration conditions with different frequencies and postures.

Study Record Dates

• First Submitted: January 28, 2026
• First Posted: February 4, 2026
• Study Start: December 15, 2025
• Primary Completion: January 25, 2026
• Study Completion: January 26, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Locations

TU (1)