Chronic and Acute Cardiovascular Diseases in Elderly Intensive Care Patients

NCT07385482 | Not Yet Recruiting

• 1 other identifier: VIP4
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

Very old patients are a rapidly growing and vulnerable population in acute cardiovascular care but remain underrepresented in clinical trials. Clinical outcomes in older intensive care unit (ICU) patients are determined less by chronological age than by their clinical phenotype, including cardiovascular comorbidities, frailty, polypharmacy, and functional and cognitive impairment. This prospective multicenter observational study aims to assess the impact of chronic and acute cardiovascular diseases on long-term outcomes and functional trajectories in older ICU patients. Using the international VIP research network, approximately 4,000 patients will be enrolled across different ICU specialties and healthcare systems and assessed multidimensionally using validated clinical scores. The study seeks to improve risk stratification and outcome prediction in older critically ill patients with cardiovascular disease and to address existing evidence gaps in acute cardiovascular and intensive care medicine.

Conditions

Chronic Cardiovascular Disease; Acute Cardiovascular Disease; Frailty

Keywords

older intensive care patients; intensive care unit; cardiovascular disease; frailty; multimorbidity; mortality; functional outcome; health-related quality of life

Outcome Measures

Primary Outcomes (1)

• mortality

  surivival or death

  within 6 months

Secondary Outcomes (4)

• Functionality and Quality of Life

  6 months

• Functionality and Quality of Life

  6 months

• Functionality and Quality of Life

  6 months

• Long-term survival and readmission rate

  up to 12 months

Other Outcomes (1)

• The combined endpoint aims to evaluate both survival outcomes and functional independence

  6 months

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study focuses on older intensive care unit patients with chronic and acute cardiovascular diseases and is coordinated across multiple international sites using standardized data collection procedures.

You may qualify if:

• years or older
• Admission to the intensive care unit
• Signed informed consent or absence of discernible indications suggesting the presumed intention of the patient not to participate in the study.

You may not qualify if:

• \< 80 years
• Absence of informed consent
• Discernible indications suggesting the presumed intention of the patient not to participate in the study.

Sponsors & Collaborators

• Heinrich-Heine University, Duesseldorf: lead

Study Sites (1)

University Hospital Duesseldorf

Düsseldorf, Germany

Location

MeSH Terms

Conditions

Frailty; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Malte Kelm, MD

  Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf

  STUDY CHAIR

• Christian Jung, MD

  Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christian Jung, MD

CONTACT

+492118118567; Christian.jung@med.uni-duesseldorf.de

Lisa Dannenberg, MD

CONTACT

+ 49211 81 05315; LisaKristina.Dannenberg@med.uni-duesseldorf.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2026
• First Posted: February 4, 2026
• Study Start: March 1, 2026
• Primary Completion: March 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: February 5, 2026

Record last verified: 2026-01

Locations

DE (1)