Impact of Chronic and Acute Cardiovascular Diseases in Older Intensive Care Patients: A Prospective Multicenter Observational Study - VIP4
Sponsor study identifier
observational
4,000
1 country
1
Study Start
March 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
March 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
March 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Very old patients are a rapidly growing and vulnerable population in acute cardiovascular care but remain underrepresented in clinical trials. Clinical outcomes in older intensive care unit (ICU) patients are determined less by chronological age than by their clinical phenotype, including cardiovascular comorbidities, frailty, polypharmacy, and functional and cognitive impairment. This prospective multicenter observational study aims to assess the impact of chronic and acute cardiovascular diseases on long-term outcomes and functional trajectories in older ICU patients. Using the international VIP research network, approximately 4,000 patients will be enrolled across different ICU specialties and healthcare systems and assessed multidimensionally using validated clinical scores. The study seeks to improve risk stratification and outcome prediction in older critically ill patients with cardiovascular disease and to address existing evidence gaps in acute cardiovascular and intensive care medicine.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 20, 2026
Actual (reported)February 4, 2026
Actual (reported)March 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
March 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
March 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
mortality
surivival or death
within 6 months
Functionality and Quality of Life
6 months
Functionality and Quality of Life
6 months
Functionality and Quality of Life
6 months
The study focuses on older intensive care unit patients with chronic and acute cardiovascular diseases and is coordinated across multiple international sites using standardized data collection procedures.
University Hospital Duesseldorf
Düsseldorf, Germany
Malte Kelm, MD
Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf
Christian Jung, MD
Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf
First Submitted
January 20, 2026
First Posted
February 4, 2026
Study Start
March 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
March 1, 2026
Estimated (date passed)Long-term survival and readmission rate
up to 12 months
The combined endpoint aims to evaluate both survival outcomes and functional independence
6 months
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
March 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
February 5, 2026
Record last verified: 2026-01
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Source: ClinicalTrials.gov.
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