Correlation of Dermoscopic Findings With Histopathological Features and Invasion Depth in Cutaneous Squamous Cell Carcinoma

NCT07384949 | Not Yet Recruiting

• 1 other identifier: ISTEAH-SCC-DERM-01
• Study Type: observational
• Target: 238
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective study including patients diagnosed with cutaneous squamous cell carcinoma between 2016 and 2025. Demographic, clinical, histopathological, and dermoscopic data were obtained from hospital records. Dermoscopic images taken with the FotoFinder dermoscope were independently evaluated by two dermatologists in a blinded manner. In addition, images were labeled using computer software and analyzed to measure the proportion of specific dermoscopic structures within the total lesion area. These quantitative data were used to examine the relationship between dermoscopic features and histopathological findings.

Conditions

Cutaneous Squamous Cell Cancer

Keywords

dermoscopy; Dermoscopic features; Histopathology correlation; Tumor invasion depth; Skin cancer imaging; Computer-assisted image analysis; Squamous cell carcinoma

Outcome Measures

Primary Outcomes (1)

• Correlation between dermoscopic features and tumor invasion depth

  The association between predefined dermoscopic features and histopathological tumor invasion depth will be evaluated using quantitative and qualitative dermoscopic assessments.

  Retrospective analysis of records from 2016 to 2025

Study Arms (1)

Cutaneous Squamous Cell Carcinoma Patients

This cohort includes patients diagnosed with cutaneous squamous cell carcinoma between 2016 and 2025 who underwent total excision and had available clinical, dermoscopic, and histopathological data in hospital records. No additional interventions were performed as part of the study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18 to 100 years who were diagnosed with cutaneous squamous cell carcinoma and treated with total surgical excision between 2016 and 2025. Only cases with complete clinical, dermoscopic, and histopathological records, including documented tumor differentiation and invasion depth, were included. No additional diagnostic or therapeutic procedures were performed as part of the study.

You may qualify if:

• Histopathologically confirmed cutaneous squamous cell carcinoma
• Lesions that underwent total surgical excision
• Histopathology reports including both tumor differentiation grade and invasion depth
• Availability of dermoscopic images obtained prior to excision
• Dermoscopic images of sufficient quality for evaluation and image analysis -

You may not qualify if:

• Lesions that received any prior treatment, including radiotherapy, chemotherapy, cryotherapy, or other destructive or topical treatments before excision
• Incomplete clinical, dermoscopic, or histopathological data
• Poor-quality dermoscopic images not suitable for reliable evaluation or segmentation

Sponsors & Collaborators

• Istanbul Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences, Istanbul Training and Research Hospital, Department of Dermatology

Istanbul, FATİH, 34098, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Carcinoma, Squamous Cell

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Squamous Cell

Central Study Contacts

AYSE ESRA KOKU AKSU, Principal Investigator

CONTACT

905059126069; esraaksu@gmail.com

SELMA NUR ŞAHİN, MD

CONTACT

905321778725; selmanur6167@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dermatology Resident, MD

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 3, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)