The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status

NCT07383974 | Recruiting

• 1 other identifier: W25002003
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status. The study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Participants will be randomly assigned to one of two groups: one group will take a combination of Nu Skin's Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules, while the other group will take a matching placebo. The primary goal is to assess if the supplement combination improves skin health after 12 weeks, measured through specialized facial imaging (assessing spots, redness, evenness) and probe measurements (assessing elasticity, moisture, gloss). Secondary goals include evaluating changes in participants' self-perceived health status (via quality of life, fatigue, and digestive health questionnaires), psychological resilience, memory, and exploring a new method for measuring skin carotenoid levels. This study is not intended to verify the approved health functions of the products but to explore the potential combined effects of antioxidant and nutritional supplementation on skin and general well-being.

Conditions

Skin Health; Healthy Volunteers; Dietary Supplementation; Health Status; Antioxidants

Outcome Measures

Primary Outcomes (7)

• Facial Image Capture VISIA-7

  Imaging sessions are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)

• Skin Elasticity Test Probe Cutometer

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)

• Skin Gloss Measurement Glossmeter

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Skin Moisture Content Corneometer

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)

• Skin Hemoglobin Measurement Mexameter MX18 (Courage & Khazaka, Germany)

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Skin Moisture Loss Meter Vapometer (Delfin, Finland)

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Skin Carotenoid Index

  Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

Secondary Outcomes (5)

• Skin Condition Survey

  The scales and questionnaires are administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Physical Health and Life Status Survey

  The survey is administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Psychological State and Memory Level

  The assessment is conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Self-Evaluation Questionnaire

  This questionnaire is administered only at follow-up visits: T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

• Height and Weight Measurement BMI

  Measurements are conducted at T0 (baseline, upon enrollment) and T12w (12 weeks).

Study Arms (2)

Supplement Combination Group

EXPERIMENTAL

Dietary Supplement: Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination

Placebo Control Group

PLACEBO COMPARATOR

Dietary Supplement: Placebo Combination (Matching)

Interventions

Placebo Combination (Matching) DIETARY_SUPPLEMENT

Participants take a matching placebo combination (identical in appearance and taste to the active supplements) orally twice daily

Placebo Control Group

Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination DIETARY_SUPPLEMENT

Participants take a combination of active supplements-specifically, Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules-orally twice daily.

Supplement Combination Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Chinese adults of Asian descent aged 18 and above;
• Daily fruit and vegetable intake \< 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);
• S3 measurement index \< 30000;
• Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;
• Voluntary participation in the test and signing of the informed consent form;
• Willingness to comply with all evaluation requirements.

You may not qualify if:

• Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;
• Skin lesions, scars, or significant pigmentation on the hand measurement area;
• Symptoms of skin disease on the face or hand measurement areas;
• Having undergone medical aesthetic procedures within the last 6 months;
• Participation in other clinical trials involving product use within the last 3 months;
• Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month;
• Currently planning for pregnancy, pregnant, or lactating;
• Presence of any disease under current treatment;
• Any other health issues or chronic diseases that affect behavioral or cognitive abilities;
• Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results.

Sponsors & Collaborators

• ChinaNorm: lead

Study Sites (1)

Shanghai China-norm Quality Technical Service Co., Ltd.

Shanghai, Shanghai Municipality, 200072, China

RECRUITING

MeSH Terms

Interventions

Ascorbic Acid; Tea; Geritol; Minerals

Intervention Hierarchy (Ancestors)

Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates; Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Inorganic Chemicals

Central Study Contacts

Yanwen Jiang

CONTACT

13501700841; jiangyanwen@china-norm.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 19, 2026
• First Posted: February 3, 2026
• Study Start: November 3, 2025
• Primary Completion: February 2, 2026
• Study Completion: February 2, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-01

Locations

CN (1)