A Multicenter Cross-sectional Study on Tinnitus Subtypes and Risk Factors

NCT07383675 | Completed

• 1 other identifier: TSM-2026
• Study Type: observational
• Target: 3,345
• Locations: 1 country
• Sites: 1

Brief Summary

Tinnitus affects an estimated 10-15% of the global population and can substantially impair quality of life, yet clinically actionable approaches for subtype identification and risk stratification remain limited. This multicenter, cross-sectional observational study will use de-identified electronic health record (EHR) data from three otolaryngology specialty hospitals in China to address these gaps. All extracted data will be de-identified with direct identifiers removed, and privacy safeguards will be implemented in accordance with institutional policies and applicable regulations to protect patient confidentiality.

Conditions

Tinnitus

Outcome Measures

Primary Outcomes (1)

• Number of Patients in Each Tinnitus Subtype

  The number of participants classified into each predefined tinnitus subtype based on an integrated diagnosis clinical classification framework.

  baseline

Secondary Outcomes (2)

• Adjusted odds ratios of risk factors associated with each tinnitus subtype

  baseline

• Accuracy of prediction models for identifying tinnitus subtype classification

  baseline

Interventions

Observational group OTHER

This is a multicenter, cross-sectional observational study using existing electronic health record data collected during routine clinical care.We will use retrospectively extracted electronic health record data from multiple otolaryngology specialty hospitals to identify risk factors and develop predictive models for tinnitus subtypes at a single index time point.

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with any type of tinnitus from three otolaryngology specialty hospitals in China

You may qualify if:

• ≥18 years old；
• Patients diagnosed with various types of tinnitus；
• Patients with available electronic medical records, including demographic and clinical information.

You may not qualify if:

• Patients with incomplete data；
• Patients with severe neurological；
• Patients with disorders that may confound tinnitus assessment.

Sponsors & Collaborators

• Chongqing Renpin ENT. Hospital, China: collaborator
• Nanjing Renpin ENT. Hospital, China: collaborator
• Chengdu Renpin ENT. Hospital, China: collaborator
• Shanghai Jiao Tong University School of Medicine: lead

Study Sites (1)

Chongqing Renpin ENT Hospital

Chongqing, China

Location

Biospecimen

Retention: NONE RETAINED

This is an observational study and no samples will be collected.

MeSH Terms

Conditions

Tinnitus

Condition Hierarchy (Ancestors)

Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Hongsheng Tan, Dr

  Shanghai Jiao Tong University School of Medicne

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 4, 2026
• First Posted: February 3, 2026
• Study Start: March 1, 2022
• Primary Completion: November 30, 2024
• Study Completion: January 16, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-01

Locations

CN (1)