NCT07382596

Brief Summary

PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomized trial will compare dextrose injection with an injection control of normal saline (NS)

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for phase_4

Timeline
36mo left

Started Mar 2026

Typical duration for phase_4

Geographic Reach
1 country

4 active sites

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress6%
Mar 2026Apr 2029

First Submitted

Initial submission to the registry

January 24, 2026

Completed
10 days until next milestone

First Posted

Study publicly available on registry

February 3, 2026

Completed
26 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2029

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2029

Last Updated

February 4, 2026

Status Verified

February 1, 2026

Enrollment Period

3 years

First QC Date

January 24, 2026

Last Update Submit

February 2, 2026

Conditions

PTSD

Keywords

DextroseHydrodissectionCervical Plexus

Outcome Measures

Primary Outcomes (1)

  • Post traumatic checklist for civilians

    Minimum 17 Maximum 85 Higher scores mean worse outcome

    3 months

Secondary Outcomes (2)

  • Hospital anxiety and depression scale

    3 months

  • EuroQol Visual Analog Scale (0-100 overall quality of life)

    3 months

Study Arms (2)

D5W cervical plexus hydrodissection

EXPERIMENTAL

10 ml D5W cervical plexus hydrodissection bilaterally at 0, 2, 4, and 8 weeks, and then by request from 13-52 weeks

Drug: Dextrose 5% in water bilateral injection

Normal saline cervical plexus hydrodissection

ACTIVE COMPARATOR

10 mL normal saline cervical plexus hydrodissection bilaterally at 0, 2, 4, and 8 weeks, and then D5W by request from 13-52 weeks

Drug: Normal saline bilateral injection

Interventions

Normal saline bilateral injectionDRUG

Injection under the investing fascia of the sternocleidomastoid muscle

Normal saline cervical plexus hydrodissection
Dextrose 5% in water bilateral injectionDRUG

Injection under the investing fascia of the sternocleidomastoid muscle

D5W cervical plexus hydrodissection

Eligibility Criteria

Age19 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Not involved in another study of PTSD treatment
  • Reliable transportation
  • Comfortable with computers
  • Tried 2 or more medications for treatment of PTSD symptoms
  • Tried 2 or more non-medication treatments for PTSD symptom
  • No known life-threatening illness
  • Not taking daily narcotics
  • Not having 3 or more alcoholic drinks on an average day
  • No active suicidal plans
  • No major surgery plans
  • No major life stress that might interfere with completing study
  • Symptoms for more than 1 year
  • Not planning to move for next 18 months.
  • Living within an hour of Portland, OR, Madison, WI, or Lexington, KY
  • Wiling to provide 2 email and 2 phone contact methods
  • +6 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Wellward Medical

Lexington, Kentucky, 40509, United States

Location

NW Regen

Portland, Oregon, 97210, United States

Location

Paul Johnson, MD.

Portland, Oregon, 97210, United States

Location

Medical Procedures of Wisconsin

Madison, Wisconsin, 53709, United States

Location

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Interventions

Glucose

Condition Hierarchy (Ancestors)

Stress Disorders, TraumaticTrauma and Stressor Related DisordersMental Disorders

Intervention Hierarchy (Ancestors)

HexosesMonosaccharidesSugarsCarbohydrates

Study Officials

  • Kenneth D Reeves, M.D.

    Dr. Dean Reeves Clinic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Kenneth D Reeves, MD

CONTACT

9133621600DeanReevesmd@gmail.com

Clare R Solso, RN

CONTACT

405 819 7777cereeves2002@hotmail.com

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
The statistician is masked as well
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized double-blind study comparing BHDCP with D5W versus NS
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 24, 2026

First Posted

February 3, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

March 1, 2029

Study Completion (Estimated)

April 1, 2029

Last Updated

February 4, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

De-identified data are available from the first author upon request in writing and with a detailed use plan.

Time Frame
10 years
Access Criteria
Request in writing

Locations

US(4)