GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension

NCT07381816 | Enrolling By Invitation

• 2 other identifiers: H-25007666NNF23OC0082437
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with postprandial hypotension.

Conditions

Blood Flow; Postprandial Hypotension; Healthy

Keywords

Physiology; GIP; Blood flow; Postprandial hypotension; Splanchnic blood flow; Mesenteric blood flow

Outcome Measures

Primary Outcomes (1)

• Blood flow

  Redistribution of splanchnic blood flow in the vessel mesenteric superior artery. Measured with functional MRI in ml/min

  145 minutes

Secondary Outcomes (2)

• Blood flow

  145 minutes

• Blood flow

  145 minutes

Study Arms (2)

Postprandial hypotension group

EXPERIMENTAL

MRI scans of PPH patients. 3 interventions

Other: MRI + GIPR antagonist (Tool); Other: MRI + hangrip; Other: Saline and oral glucose

Healthy matched controls

PLACEBO COMPARATOR

MRI scans of healthy controls. Crossover design three interventions.

Other: MRI + GIPR antagonist (Tool); Other: MRI + hangrip; Other: Saline and oral glucose

Interventions

MRI + GIPR antagonist (Tool) OTHER

GIP(3-30)NH2 infusion, oral glucose during MRI scans

Healthy matched controls; Postprandial hypotension group

MRI + hangrip OTHER

Hangrip exercises, oral glucose during MRI scans

Healthy matched controls; Postprandial hypotension group

Saline and oral glucose OTHER

Saline infusion oral glucose during MRI scans

Healthy matched controls; Postprandial hypotension group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Postprandial hypotension
• Symptoms of postprandial hypotension

You may not qualify if:

• Treatment with drugs that cannot be paused for 12 hours
• Metallic implants that does not tolerate MRI
• Any other disease or dysfunction that may disturb blood flow to the gut
• Intake of more than 14 units of alcohol per week or abuse of drugs
• Blood vessels that are not feasible for measuring flow in the MRI scanner
• Low blood percent
• Decreased kidney function
• Decreased liver function
• Claustrophobia
• For the healthy group
• Matched by age, gender and BMI
• Postprandial hypotension
• Metallic implants that does not tolerate MRI
• Intake of more than 14 units of alcohol per week or abuse of drugs
• Blood vessels that are not feasible for measuring flow in the MRI scanner

Sponsors & Collaborators

• Rigshospitalet, Denmark: collaborator
• University of Copenhagen: lead

Study Sites (1)

Glostrup hospital

Glostrup Municipality, 2600, Denmark

Location

MeSH Terms

Interventions

Magnetic Resonance Spectroscopy; Equipment and Supplies; Sodium Chloride; Glucose

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Chlorides; Hydrochloric Acid; Chlorine Compounds; Inorganic Chemicals; Sodium Compounds; Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Single blind, placebo controlled, randomized, crossover study

Study Record Dates

• First Submitted: September 3, 2025
• First Posted: February 2, 2026
• Study Start: September 15, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): May 1, 2027
• Last Updated: February 2, 2026

Record last verified: 2025-09

Locations

DK (1)