NCT07381036

Brief Summary

The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST.

  • Primary outcome
  • To compare the incidence of POST method.
  • Secondary outcomes
  • Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative.
  • The hemodynamics recording (HR, BP, MBP, pre and post nebulization)
  • Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P75+ for not_applicable

Timeline
4mo left

Started Feb 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress45%
Feb 2026Sep 2026

First Submitted

Initial submission to the registry

January 22, 2026

Completed
10 days until next milestone

Study Start

First participant enrolled

February 1, 2026

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 2, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

February 3, 2026

Status Verified

January 1, 2026

Enrollment Period

5 months

First QC Date

January 22, 2026

Last Update Submit

January 30, 2026

Conditions

Postoperative Sore Throat

Outcome Measures

Primary Outcomes (1)

  • To compare the incidence of Post operative sore throat method.

    24 hours

Study Arms (3)

Ketamine group

EXPERIMENTAL
Drug: Ketamine nebulizer

Mg sulfate group

EXPERIMENTAL
Drug: Mg sulfate nebulizer

Placebo group

PLACEBO COMPARATOR
Drug: Placebo

Interventions

Ketamine nebulizerDRUG

50 patients will receive preoperative nebulization with 50 mg ketamine in 5 ml normal saline.

Ketamine group
Mg sulfate nebulizerDRUG

50 patients will receive preoperative nebulization with 250 mg magnesium sulfate in 5 ml normal saline.

Mg sulfate group
PlaceboDRUG

50 patients will receive preoperative nebulization with 5 ml normal saline.

Placebo group

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age from 18 to 65 years old.
  • Both sexes.
  • American Society of Anesthesiologists (ASA) physical status I-II.
  • Elective surgery requiring GA with endotracheal intubation.

You may not qualify if:

  • Surgery involves the oral cavity, nasopharynx, larynx, and neck regions.
  • Surgery requires prone position.
  • Surgery lasted more than 3 hours.
  • History of preoperative sore throat, common cold.
  • Anticipated difficult airway.
  • Any known allergies to study drugs.
  • Recent non-steroidal anti-inflammatory drugs use.
  • Pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Central Study Contacts

Shahenda AHMED Ali, Resident

CONTACT

01153378581Shahenda_ahmed_post@med.sohag.edu.eg

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident of Anesthesia and surgical Intensive Care unit and Pain Management

Study Record Dates

First Submitted

January 22, 2026

First Posted

February 2, 2026

Study Start

February 1, 2026

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

February 3, 2026

Record last verified: 2026-01