Double Triggering Asynchrony in Mechanically Ventilated Patients.

NCT07380607 | Completed

• 1 other identifier: MD.24.03.838.R1
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem affects critically ill patients. Findings may help improve ventilator care in intensive care units.

Conditions

Respiratory Failure; Critical Illness; Mechanical Ventilation

Keywords

Double Triggering; Patient-Ventilator Asynchrony; Diaphragmatic Ultrasound; Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• Sensitivity of diaphragmatic ultrasound for detection of double triggering asynchrony

  Proportion of double triggering asynchrony events correctly identified by diaphragmatic ultrasound compared with ventilator waveform analysis as the reference standard

  During ICU admission, at the time of double triggering detection by ventilator graph interpretation

Study Arms (1)

Double Triggering Cohort

28mechanically ventilated ICU patients identified with double triggering asynchrony

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (\>18 years) admitted to medical/surgical ICU at Specialized Medical Hospital, Mansoura University, receiving invasive mechanical ventilation with documented double triggering asynchrony on ventilator waveform analysis.

You may qualify if:

• Adult ICU patients aged ≥18 years receiving invasive mechanical ventilation
• Documented double triggering asynchrony on ventilator waveform analysis.

You may not qualify if:

• Patients with contraindications to diaphragmatic ultrasound, including thoracic or abdominal surgery.
• Patients with known diseases affecting diaphragmatic function, such as Duchenne muscular dystrophy (DMD) or myasthenia gravis (MG).
• Patients with advanced chronic liver disease (Child-Pugh class C)
• Patients with chronic increased intra-abdominal pressure.
• Patients with moderate to massive pleural effusion.
• Patient or legal guardian refusal to participate in the study.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Specialised Medical Hospital - ICU

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Location

MeSH Terms

Conditions

Respiratory Insufficiency; Critical Illness; Patient-Ventilator Asynchrony

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2026
• First Posted: February 2, 2026
• Study Start: November 5, 2024
• Primary Completion: October 20, 2025
• Study Completion: November 2, 2025
• Last Updated: April 15, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)