Effects of Patients' Hormone Levels on Sedoanalgesia

NCT07378241 | Not Yet Recruiting

• 1 other identifier: Oocyte Pick Up
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Investigastors hypothesis is that the need for anaesthetic agents is less in patients with high progesterone levels and more in patients with high estrogen levels.

Conditions

Consumption of Anaesthetic Agents; Sedoanalgesia

Keywords

sedoanalgesia; OPU; Progesterone; estrogen

Outcome Measures

Primary Outcomes (1)

• Anesthetic consumptiom

  the amount of propofol needed to provide adequate depth of anaesthesia in mg/kg/minute

  intraoperative

Secondary Outcomes (3)

• Pulse oximeter

  intraoperative

• hearth rate changes

  intraoperative

• Blood pressure changes

  intraoperative

Study Arms (1)

OPU patients

patients progesteron estrogen levels and progesteron/estrogen ratios

Drug: Anesthesia Maintenance

Interventions

Anesthesia Maintenance DRUG

the amount of propofol required to achieve depth of anaesthesia in mg/kg/minute

OPU patients

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Between 18-45 years old * ASA-I ASA-II patients who were sedated for oocyte pick-up between 1 June 2025 and 1 September 2025 at Izmir City Hospital * Patients whose hormone levels were measured in the preoperative period due to surgical indication and registered in the hospital data processing system

You may qualify if:

• Between 18-45 years old
• ASA-I ASA-II patients who were sedated for oocyte pick-up between 1 June 2025 and 1 September 2025 at Izmir City Hospital
• Patients whose hormone levels were measured in the preoperative period due to surgical indication and registered in the hospital data processing system

You may not qualify if:

• Lack of patient approvel
• Diagnosed psychiatric disorder
• Use of drugs affecting the central nervous system
• Presence of chronic pain syndrome
• History of continuous analgesic use due to chronic pain
• Hepatic and/or renal insufficiency
• BMI\>30
• Changing the method of anaesthesia for any reason

Sponsors & Collaborators

• Izmir City Hospital: lead

Related Publications (1)

• Lee J, Lee J, Ko S. The relationship between serum progesterone concentration and anesthetic and analgesic requirements: a prospective observational study of parturients undergoing cesarean delivery. Anesth Analg. 2014 Oct;119(4):901-905. doi: 10.1213/ANE.0000000000000366.

  PMID: 25036373 RESULT

Study Officials

• Halide Hande Şahinkaya, MD

  Izmir City Hospital, Anesthesiology and Reanimation Department

  STUDY CHAIR

• Tuba Kuvvet Yoldaş, MD

  Izmir City Hospital, Anesthesiology and Reanimation Department

  STUDY CHAIR

• Zeki Tuncer Tekgul, Prof. Dr.

  Izmir City Hospital, Anesthesiology and Reanimation Department

  STUDY CHAIR

Central Study Contacts

GOZDE GURSOY CIRKINOGLU, MD

CONTACT

00905544071757; dr.gozde.gursoy@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: May 26, 2025
• First Posted: January 30, 2026
• Study Start: January 30, 2026
• Primary Completion: March 1, 2026
• Study Completion: April 30, 2026
• Last Updated: January 30, 2026

Record last verified: 2025-12