NCT07377851

Brief Summary

This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training. Carbonic anhydrase II is an enzyme involved in acid-base balance and carbon dioxide transport, and it may reflect physiological adaptations to intense exercise. Healthy basketball players participated in a structured high-intensity interval training program designed to reflect the physical demands of basketball. Blood samples and performance-related measurements were collected before and after the training period to evaluate changes in erythrocyte carbonic anhydrase II levels and related metabolic responses. The findings of this study are expected to improve the understanding of exercise-induced metabolic adaptations and to explore the potential use of erythrocyte carbonic anhydrase II as a practical biomarker for monitoring training responses in basketball players.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 10, 2026

Completed
5 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2026

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

January 22, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 30, 2026

Completed
Last Updated

January 30, 2026

Status Verified

January 1, 2026

Enrollment Period

2 months

First QC Date

January 22, 2026

Last Update Submit

January 28, 2026

Conditions

Metabolic Adaptation to High-Intensity Interval Training

Keywords

Carbonic Anhydrase IIExercise PhysiologyMetabolic AdaptationHigh-Intensity Interval TrainingBasketball Training

Outcome Measures

Primary Outcomes (1)

  • Change in Erythrocyte Carbonic Anhydrase II Levels

    The primary outcome is the change in erythrocyte carbonic anhydrase II levels measured before and after the basketball-specific high-intensity interval training program. Erythrocyte carbonic anhydrase II was assessed from blood samples as an indicator of metabolic adaptation to high-intensity exercise.

    Baseline( week 0) and post training (week 8)

Study Arms (1)

Basketball-Specific High-Intensity Interval Training

EXPERIMENTAL

Participants completed a basketball-specific high-intensity interval training program designed to induce metabolic adaptations. All participants were assigned to this single intervention arm and completed the same training protocol.

Behavioral: Basketball-Specific High-Intensity Interval Training

Interventions

Basketball-Specific High-Intensity Interval TrainingBEHAVIORAL

A structured basketball-specific high-intensity interval training program consisting of repeated bouts of intense exercise interspersed with short recovery periods, designed to induce metabolic adaptations.

Basketball-Specific High-Intensity Interval Training

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy male and female basketball players aged 18 years or older
  • Actively participating in regular basketball training at the time of the study
  • Free from known cardiovascular, metabolic, or respiratory diseases
  • No musculoskeletal injury that could limit participation in high-intensity exercise
  • Willingness to participate in a basketball-specific high-intensity interval training program
  • Ability to provide written informed consent

You may not qualify if:

  • Presence of any diagnosed cardiovascular, metabolic, or respiratory disease
  • Use of medications or supplements known to affect metabolic or acid-base balance
  • Acute or chronic musculoskeletal injury within the previous three months
  • Participation in another structured training or research intervention during the study period
  • Failure to comply with the training protocol or assessment procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karamanoğlu Mehmetbey University, Faculty of Sport Sciences

Karaman, Karaman, 70200, Turkey (Türkiye)

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Masking Details
No additional parties were masked. The study was conducted as an open-label trial.
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

January 22, 2026

First Posted

January 30, 2026

Study Start

November 1, 2025

Primary Completion

January 10, 2026

Study Completion

January 15, 2026

Last Updated

January 30, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)