Comparative Study of CPAP Predictive Equations and In-laboratory Manual Titration in Thai Patients With Obstructive Sleep Apnea

NCT07376343 | Recruiting

• 1 other identifier: TUH-EC-OO-0-031/68
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA). The main question the study aims to answer is: Which CPAP predictive equation best predicts the optimal CPAP pressure in OSA patients in Thailand? Participants will undergo an in-laboratory sleep study.

Conditions

OSA - Obstructive Sleep Apnea

Keywords

OSA; obstructive sleep apnea; CPAP; continuous positive airway pressure; equation; Thailand; sleep test; polysomnography

Outcome Measures

Primary Outcomes (1)

• Accuracy of CPAP equations in predicting the optimal pressure in OSA patients

  Sensitivity and specificity (%) of CPAP equations in predicting the optimal pressure in OSA patients

  At baseline

Study Arms (1)

Obstructive sleep apnea (OSA)

Patients aged 18 years or older with OSA

Diagnostic Test: Sleep test; Other: Predictive equations of continuous positive airway pressure (CPAP)

Interventions

Sleep test DIAGNOSTIC_TEST

Type 1 polysomnography will be performed in the Sleep Center of Thammasat (SCENT).

Obstructive sleep apnea (OSA)

Predictive equations of continuous positive airway pressure (CPAP) OTHER

CPAP predictive equations will be selected based on evidence from reliable studies.

Obstructive sleep apnea (OSA)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18 years or older with suspected OSA

You may qualify if:

• Suspected OSA
• Undergoing an in-laboratory sleep study

You may not qualify if:

• No indication for in-laboratory manual CPAP titration
• Failure to determine an optimal CPAP pressure during in-laboratory manual CPAP titration

Sponsors & Collaborators

• Thammasat University: lead

Study Sites (2)

Faculty of Medicine, Thammasat University

Pathum Thani, 12120, Thailand

RECRUITING

Narongkorn Saiphoklang

Pathum Thani, 12120, Thailand

RECRUITING

Related Publications (11)

• Lin IF, Chuang ML, Liao YF, Chen NH, Li HY. Predicting effective continuous positive airway pressure in Taiwanese patients with obstructive sleep apnea syndrome. J Formos Med Assoc. 2003 Apr;102(4):215-21.

  PMID: 12833183 RESULT

• Chuang ML, Lin IF, Vintch JR, Liao YF. Predicting continuous positive airway pressure from a modified split-night protocol in moderate to severe obstructive sleep apnea-hypopnea syndrome. Intern Med. 2008;47(18):1585-92. doi: 10.2169/internalmedicine.47.1107. Epub 2008 Sep 16.

  PMID: 18797117 RESULT

• Luo J, Xiao S, Qiu Z, Song N, Luo Y. Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea. Respirology. 2013 Apr;18(3):528-33. doi: 10.1111/resp.12014.

  PMID: 23145885 RESULT

• Wu MF, Hsu JY, Huang WC, Shen GH, Wang JM, Wen CY, Chang KM. Should sleep laboratories have their own predictive formulas for continuous positive airway pressure for patients with obstructive sleep apnea syndrome? J Chin Med Assoc. 2014 Jun;77(6):283-9. doi: 10.1016/j.jcma.2014.02.015. Epub 2014 Apr 14.

  PMID: 24731756 RESULT

• Pang F, Deng W, Huang J, Guo Y, Lin M, Zhang X, Liu J. Prediction of Optimal Positive Airway Pressure in Chinese Patients With Obstructive Sleep Apnea. Clin Respir J. 2024 Dec;18(12):e70047. doi: 10.1111/crj.70047.

  PMID: 39716408 RESULT

• Choi JH, Kim EJ, Kim KW, Choi J, Kwon SY, Lee HM, Kim TH, Lee SH, Shin C, Lee SH. Optimal continuous positive airway pressure level in korean patients with obstructive sleep apnea syndrome. Clin Exp Otorhinolaryngol. 2010 Dec;3(4):207-11. doi: 10.3342/ceo.2010.3.4.207. Epub 2010 Dec 22.

  PMID: 21217962 RESULT

• Lee GH, Kim MJ, Lee EM, Kim CS, Lee SA. Prediction of optimal CPAP pressure and validation of an equation for Asian patients with obstructive sleep apnea. Respir Care. 2013 May;58(5):810-5. doi: 10.4187/respcare.01860.

  PMID: 23051618 RESULT

• Sarma L, Putti N, Alias K, Chilana M. Determination of equation for estimating continuous positive airway pressure in patients with obstructive sleep apnea for the Indian population. Lung India. 2020 Sep-Oct;37(5):411-414. doi: 10.4103/lungindia.lungindia_322_19.

  PMID: 32883901 RESULT

• Bamagoos AA, Alshaynawi SA, Gari AS, Badawi AM, Alhiniah MH, Alshahrani AA, Rajab RR, Bahaj RK, Alhejaili F, Wali SO. Optimal positive airway pressure requirement and polysomnography indices of obstructive sleep apnea severity in the Saudi population. Ann Thorac Med. 2023 Jan-Mar;18(1):31-38. doi: 10.4103/atm.atm_183_22. Epub 2023 Jan 25.

  PMID: 36968331 RESULT

• Ebben MR, Narizhnaya M, Krieger AC. A new predictive model for continuous positive airway pressure in the treatment of obstructive sleep apnea. Sleep Breath. 2017 May;21(2):435-442. doi: 10.1007/s11325-016-1436-7. Epub 2016 Nov 22.

  PMID: 27878543 RESULT

• Saiphoklang N, Leelasittikul K, Pugongchai A. Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea. Sci Rep. 2021 Jul 6;11(1):13935. doi: 10.1038/s41598-021-93554-5.

  PMID: 34230571 RESULT

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Interventions

Polysomnography

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Monitoring, Physiologic; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Narongkorn Saiphoklang

  Thammasat University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Narongkorn Saiphoklang, MD

CONTACT

+6629269794; M_narongkorn@hotmail.com

Apiwat Pugongchai, MSc

CONTACT

+669269142; pu.apiwat@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 17, 2026
• First Posted: January 29, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: IPD and documents will be available for sharing immediately after publication for a period of 2 years.

Locations

TH (2)