Growth in Infants With Congenital Heart Disease at AUCH

NCT07373873 | Not Yet Recruiting

• 1 other identifier: FMASU-PED-CHD-Growth-001
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 2

Brief Summary

Children with congenital heart disease (CHD) often experience growth problems. This study aims to assess and compare the growth (weight, height, head circumference) of infants and children with CHD against the expected growth standards for healthy children. This is a retrospective study that will review the medical records of children aged 1 month to 2 years who were diagnosed with CHD at Assiut University Children Hospital. The study will help understand how different types of CHD affect a child's growth, which is important for improving their nutritional care and overall management.

Conditions

Congenital Heart Disease (CHD)

Outcome Measures

Primary Outcomes (1)

• Weight-for-age z-score in children with congenital heart disease

  Comparison of the mean weight-for-age z-score in children with congenital heart disease (CHD) against the standard population mean (z-score = 0) using WHO or Egyptian growth reference charts.

  At study enrollment (data extracted from medical records for age points 6, 12, and 18 months where available).

Study Arms (1)

CHD Group

Infants and children aged 1 month to 2 years who were diagnosed with congenital heart disease (CHD) by echocardiography at Assiut University Children Hospital. This is a retrospective cohort; data on anthropometric measurements (weight, height/length, head circumference), type of CHD (cyanotic vs. acyanotic), and clinical history are collected from existing medical records. The growth parameters of this cohort will be compared against standard WHO or Egyptian growth reference charts to assess the impact of CHD on somatic growth.

Eligibility Criteria

• Age: 1 Month - 2 Years
• Gender Eligibility Details: The study involves analysis of existing medical records. Eligibility for data inclusion is based on the biological sex (male or female) recorded in the patient's file at the time of clinical care, as growth reference standards are sex-specific. The study does not involve prospective recruitment where self-identified gender would be assessed.
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of infants and young children (aged 1 month to 2 years) who were diagnosed with congenital heart disease (CHD) by echocardiography and were followed at the Pediatric Cardiology Unit of Assiut University Children Hospital. This is a retrospective cohort; participants are identified through a review of existing hospital medical records. The population includes patients with various types of CHD (both cyanotic and acyanotic) who have not yet undergone corrective cardiac surgery or intervention.

You may qualify if:

• Children aged 1 month to 2 years.
• Diagnosis of congenital heart disease (CHD) confirmed by echocardiography.
• Availability of anthropometric data in the medical record.

You may not qualify if:

• Presence of a known genetic syndrome or major extracardiac anomalies.
• Pre-existing endocrine or metabolic disorder affecting growth.
• Preterm birth (gestational age \<37 weeks).
• Previous surgical/interventional procedure for CHD.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (2)

Assuit University Children Hospital - Cardiology Department

Asyut, 71515, Egypt

Location

Assuit University Children Hospital

Asyut, 71515, Egypt

Location

MeSH Terms

Conditions

Heart Defects, Congenital

Condition Hierarchy (Ancestors)

Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Emad-Eldeen Mahmoud Hammad mo Hammad, prof

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Lamiaa Mo Hussein, Resident

CONTACT

01025347563; tahaishaq27@gmail.com

Amr Mo Kotb, Lecturer

CONTACT

01001936031; Amrkotb336@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Doctor at Al-Mabrah Hospital

Study Record Dates

• First Submitted: January 16, 2026
• First Posted: January 28, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: January 28, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (2)