NCT07373197

Brief Summary

The goal of our study to evaluate effect of lateral rectus muscle strangulation as a novel effective weakening technique in cases of exotropia. It is a case-series intervensional study with a total 12 participant who are diagnosed as exophoria or intermittent exotropia who are older than 4 years old. All patients will be assessed regarding their angle of deviation and then undergo lateral rectus muscle strangulation under general anesthesia and then will be followed- up at 1st day, 1st week, 1st month and 6th months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2024

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2024

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2024

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 2, 2025

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

September 25, 2025

Completed
4 months until next milestone

First Posted

Study publicly available on registry

January 28, 2026

Completed
Last Updated

January 28, 2026

Status Verified

September 1, 2025

Enrollment Period

6 months

First QC Date

September 25, 2025

Last Update Submit

January 22, 2026

Conditions

Keywords

ExotropiaLateral rectus muscle

Outcome Measures

Primary Outcomes (1)

  • Correction of strabismus

    the correction was done by lateral rectus muscle strangulation

    12 months

Secondary Outcomes (1)

  • orthophoria

    12 months

Study Arms (1)

lateral rectus muscle strangulation

EXPERIMENTAL

lateral rectus muscle strangulation as a weakening technique in cases of exotropia.

Procedure: Muscle strangulation

Interventions

lateral rectus muscle strangulation as a weakening technique in cases of exotropia.

lateral rectus muscle strangulation

Eligibility Criteria

Age15 Years - 50 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • intermittent exotropia

You may not qualify if:

  • previous squint surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sohag University

Sohag, Egypt

Location

Related Publications (3)

  • Rageh MA, Awadein A, Arfeen SA. Extraocular muscle fenestration: a novel weakening procedure. Can J Ophthalmol. 2020 Oct;55(5):455-457. doi: 10.1016/j.jcjo.2020.05.018. Epub 2020 Aug 26. No abstract available.

    PMID: 32860744BACKGROUND
  • Taher SG, Rageh MA, Hashem O. Extra Ocular Muscle Fenestration as a Weakening Maneuver for Surgical Management of Strabismus: A Randomized Pilot Clinical Trial. Clin Ophthalmol. 2022 Jan 8;16:63-70. doi: 10.2147/OPTH.S347092. eCollection 2022.

    PMID: 35035214BACKGROUND
  • Koc F, Ozal H, Yasar H, Firat E. Resolution in partially accomodative esotropia during occlusion treatment for amblyopia. Eye (Lond). 2006 Mar;20(3):325-8. doi: 10.1038/sj.eye.6701874.

    PMID: 15933753BACKGROUND

Related Links

MeSH Terms

Conditions

Exotropia

Condition Hierarchy (Ancestors)

StrabismusOcular Motility DisordersCranial Nerve DiseasesNervous System DiseasesEye Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

September 25, 2025

First Posted

January 28, 2026

Study Start

January 1, 2024

Primary Completion

July 1, 2024

Study Completion

February 2, 2025

Last Updated

January 28, 2026

Record last verified: 2025-09

Locations