Effects of Vagus Nerve Stimulation on the Autonomic Nervous System

NCT07371676 | Completed

• 1 other identifier: 19.04.2024/05
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to determine the effect of vagus nerve stimulation, applied after running exercise, on recovery and fatigue in healthy young adults.

Conditions

Auricular Vagus Nerve Stimulation; Transcutaneous; Recovery

Outcome Measures

Primary Outcomes (1)

• Assessment of the autonomic nervous system.

  Using heart rate variability (HRV) measurements recorded

  Periprocedural

Secondary Outcomes (1)

• Lactic acid concentrate indicator

  Periprocedural

Study Arms (2)

Vagus nerve stimulation group

EXPERIMENTAL

Device: Stimulation

Control Group

NO INTERVENTION

Interventions

Stimulation DEVICE

Recovery in athletes through vagus nerve stimulation

Vagus nerve stimulation group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being healthy between the ages of 18-35
• Volunteering to participate in the study
• Signing the voluntary consent form
• Being in the inactive category according to the International Physical Activity Questionnaire

You may not qualify if:

• Having a regular exercise habit
• Being in the very minimally active or active category according to the International Physical Activity Survey
• Presence of any chronic disease and medication use for this condition
• History and treatment of current respiratory system disease
• History and treatment of current cardiac system disease
• History and treatment of current hearing system disease

Sponsors & Collaborators

• Istanbul Gelisim University: lead

Study Sites (1)

Istanbul Gelisim University

Istanbul, Turkey (Türkiye)

Location

Related Publications (3)

• Kim AY, Marduy A, de Melo PS, Gianlorenco AC, Kim CK, Choi H, Song JJ, Fregni F. Safety of transcutaneous auricular vagus nerve stimulation (taVNS): a systematic review and meta-analysis. Sci Rep. 2022 Dec 21;12(1):22055. doi: 10.1038/s41598-022-25864-1.

  PMID: 36543841 BACKGROUND

• Ackland GL, Patel ABU, Miller S, Gutierrez Del Arroyo A, Thirugnanasambanthar J, Ravindran JI, Schroth J, Boot J, Caton L, Mein CA, Abbott TEF, Gourine AV. Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial. Eur Heart J. 2025 May 2;46(17):1634-1644. doi: 10.1093/eurheartj/ehaf037.

  PMID: 39969124 BACKGROUND

• Hatik SH, Arslan M, Demirbilek O, Ozden AV. The effect of transcutaneous auricular vagus nerve stimulation on cycling ergometry and recovery in healthy young individuals. Brain Behav. 2023 Dec;13(12):e3332. doi: 10.1002/brb3.3332. Epub 2023 Nov 16.

  PMID: 37974551 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 29, 2025
• First Posted: January 28, 2026
• Study Start: September 17, 2024
• Primary Completion: May 6, 2025
• Study Completion: December 5, 2025
• Last Updated: January 28, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)