Exercise Echocardiography Registry for Ischemic and Non-Ischemic Heart Disease

NCT07367893 | Recruiting

• 1 other identifier: Exercise-Echo Registry
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise echocardiography is a widely used non-invasive test that evaluates cardiac structure and function during physical stress. It provides important information on myocardial ischemia, cardiac performance, hemodynamic responses, and exercise capacity in patients with a broad range of heart diseases. However, real-world prospective data integrating exercise echocardiographic findings across both ischemic and non-ischemic heart disease remain limited. This prospective observational registry aims to systematically collect clinical, exercise, and echocardiographic data from patients undergoing clinically indicated exercise echocardiography. The registry includes patients with suspected or established ischemic heart disease as well as those with non-ischemic cardiac conditions, such as cardiomyopathies, heart failure, valvular heart disease, and exercise-related symptoms. The collected data will be used to evaluate exercise-induced changes in cardiac structure and function, identify phenotypes associated with adverse clinical outcomes, and improve risk stratification in routine clinical practice. The registry is observational in nature and does not alter standard clinical care.

Conditions

Non-ischemic Heart Disease; Ischemic Heart Diease

Keywords

Exercise echocardiography; Ischemic heart disease; non-ischemic heart disease; clinical outcome

Outcome Measures

Primary Outcomes (1)

• Change in left ventricular ejection fraction (LVEF) measured by transthoracic echocardiography (TTE)

  Left ventricular ejection fraction (LVEF) will be assessed by transthoracic echocardiography (TTE) using the biplane method of disks (modified Simpson's method), and the change from baseline to 1 year will be analyzed.

  Baseline and 1 year

Secondary Outcomes (2)

• Composite of cardiovascular death and hospitalization for worsening heart failure (HF) assessed by clinical event adjudication

  Up to 1 year

• Change in exercise capacity (metabolic equivalents, METs) measured by symptom-limited exercise test

  Baseline and 1 year

Study Arms (1)

Eligible participants include adult patients referred for exercise echocardiography

Eligible participants include adult patients referred for exercise echocardiography for evaluation of: * Suspected or known ischemic heart disease * Non-ischemic heart disease, including cardiomyopathy, heart failure, valvular heart disease, or structural heart disease * Exercise-related symptoms such as dyspnea, chest discomfort, or reduced exercise tolerance

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population includes adult patients who undergo clinically indicated exercise echocardiography as part of routine cardiovascular care. Participants are referred for evaluation of suspected or established ischemic heart disease as well as a broad range of non-ischemic heart diseases, including cardiomyopathy, heart failure, valvular heart disease, and structural heart disease. Patients are required to be able to perform exercise-based stress testing using standard treadmill or bicycle protocols and to have interpretable echocardiographic images obtained at rest and during exercise. This registry reflects a real-world clinical population in which exercise echocardiography is used for diagnostic and prognostic assessment across diverse cardiovascular conditions.

You may qualify if:

• Adults aged 18 years or older
• Patients referred for clinically indicated exercise echocardiography as part of routine clinical care
• Patients evaluated for suspected or known ischemic heart disease, or non-ischemic heart disease, including but not limited to: Cardiomyopathy, Heart failure, Valvular heart disease, Structural heart disease
• Ability to perform exercise-based stress testing using treadmill or bicycle protocols
• Availability of baseline clinical data and interpretable echocardiographic images obtained during rest and exercise
• Provision of informed consent, or eligibility for consent waiver in accordance with institutional review board approval

You may not qualify if:

• Inability to perform exercise testing due to non-cardiac limitations, such as severe orthopedic, neurologic, or pulmonary conditions
• Poor echocardiographic image quality that does not allow meaningful interpretation of exercise-induced changes
• Any condition deemed by the treating physician to make participation inappropriate or unsafe, even within an observational framework

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Yonsei University Yongin Severance Hospital

Yongin, Gyeonggi-do, 16995, South Korea

RECRUITING

MeSH Terms

Conditions

Myocardial Ischemia

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Central Study Contacts

SungA Bae, MD., PhD.

CONTACT

+821023273578; cardiobsa@yuhs.ac

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 26, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2035
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

KR (1)