Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients

NCT07367386 | Completed

• 1 other identifier: MRC-01-24-905
• Study Type: observational
• Target: 1,917
• Locations: 1 country
• Sites: 1

Brief Summary

This study seeks to compare the success rates, feto-maternal outcomes, and complications associated with different neuraxial blocks in Class III obese parturient undergoing cesarean section

Conditions

Neuraxial Blocks

Keywords

Neuraxial blocks; Obesity; Parturient; Cesarean

Outcome Measures

Primary Outcomes (1)

• Failed neuraxial block

  Determine the occurrence of the conversion to general anesthesia

  From onset of block until surgery completion

Secondary Outcomes (2)

• Maternal adverse events

  From onset of blockade until surgery completion

• Fetal outcomes

  At one and five minutes after birth

Study Arms (1)

Class III obese parturient

Class III obese parturient undergoing cesarean section under neuraxial block

Procedure: Neuraxial anesthesia

Interventions

Neuraxial anesthesia PROCEDURE

Single-shot spinal anesthesia

Class III obese parturient

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Class III Obese parturients undergoing C-section under neuraxial blocks in the operating rooms of Women's Wellness and Research Center from 1 January 2025 to 1 December 2024.

You may qualify if:

• Age \> or equal to 18 years
• BMI ≥ 45 kg/m²
• Gestational age ≥ 28 weeks

You may not qualify if:

• Age \< 18 years
• BMI \< 45 kg/m²
• History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke)
• Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies
• Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency)
• In utero fetal demise (IUFD)
• Failed operative vaginal delivery
• Cesarean for the second twin or multiple pregnancies (triplets or higher)
• IVF pregnancy
• Intraoperative bleeding\>1500mL
• Emergency cesarean section (Category I)
• Presence of large uterine fibroid ≥10 cm

Sponsors & Collaborators

• Mariah Arif: lead

Study Sites (1)

Women's Wellness and Research Center

Doha, Qatar

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Ayten Saracoglu

  University of Florida, UF Health, Jacksonville, FL 32209, USA

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: January 16, 2026
• First Posted: January 26, 2026
• Study Start: February 2, 2025
• Primary Completion: December 31, 2025
• Study Completion: January 1, 2026
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

QA (1)