Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries
SDF and AgF
Clinical Efficacy and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride to Arrest Incipient Carious Lesions in Permanent Molar Teeth With or Without Application of LED Light: A Randomized Clinical Trial
1 other identifier
interventional
366
0 countries
N/A
Brief Summary
The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light application on caries arrest of initial enamel pits and fissure caries for permanent teeth of young adults
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 18, 2025
CompletedFirst Posted
Study publicly available on registry
January 26, 2026
CompletedStudy Start
First participant enrolled
March 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2027
January 26, 2026
January 1, 2026
1.3 years
December 18, 2025
January 16, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Caries arrest
Lesion activity will be assessed by caries status (active/inactive) using visual and tactile inspection for surface discontinuities and texture. The participants will be examined under unit light using a 0.5 mm ball-ended (CPI) probe and a dental mirror. The teeth will be cleaned and dried by a water-air spray syringe before the examination.
After 3, 6, and 12 months.
Study Arms (6)
Pits and fissures receive International Silver Diamine Fluoride for caries arrest
ACTIVE COMPARATORRemineralization and prevention of incipient pits and fissure caries of permanent molars by International Silver Diamine Fluoride application for 60 seconds
Pits and fissures receive Local brand Egyptian Sliver Diamine Fluoride for caries arrest
EXPERIMENTALRemineralization and prevention of incipient pits and fissure caries of permanent molars by local brand Egyptian Silver Diamine Fluoride application for 60 seconds
Pits and fissures receive Sliver Fluoride for caries arrest
EXPERIMENTALRemineralization and prevention of incipient pits and fissure caries of permanent molars by Silver Fluoride application for 60 seconds
Pits and fissures receive International Silver Diamine Fluoride with LED for caries arrest
EXPERIMENTALRemineralization and prevention of incipient pits and fissure caries of permanent molars by Silver Diamine Fluoride application for 10 seconds, followed by the application LED light for 20 seconds
Pits and fissures receive local brand Egyptian Silver Diamine Fluoride with LED for caries arrest
EXPERIMENTALRemineralization and prevention of incipient pits and fissure caries of permanent molars by local brand Egyptian Silver Diamine Fluoride application for 10 seconds, followed by LED light for 20 seconds
Pits and fissures receive Sliver Fluoride with LED for caries arrest
EXPERIMENTALRemineralization and prevention of incipient pits and fissure caries of permanent molars by Silver Fluoride application for 10 seconds, followed by application of LED light for 20 seconds
Interventions
It is the gold standard; it is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
It is a water-based remineralizing agent with an application time of 60 seconds.
It is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.
It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED application for 20 seconds.
It is a water-based remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.
Eligibility Criteria
You may qualify if:
- high caries risk dental students
- Males or females
- Medically free
- Not taking medication
- At least had one active carious tooth
- Posterior permanent teeth
- ICDAS 2
You may not qualify if:
- non-Egyptian students
- Lack of compliance
- Allergic reaction to the materials used
- Pregnancy
- Dental students cannot give consent
- Teeth that will be extracted for orthodontic reasons
- Dental fluorosis
- Hypo calcified teeth
- Systemic diseases affecting teeth, such as amelogenesis imperfecta
- Severe periodontal affection
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
MeSH Terms
Interventions
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer Assistant
Study Record Dates
First Submitted
December 18, 2025
First Posted
January 26, 2026
Study Start
March 1, 2026
Primary Completion (Estimated)
June 1, 2027
Study Completion (Estimated)
July 1, 2027
Last Updated
January 26, 2026
Record last verified: 2026-01