NCT07365813

Brief Summary

Testing gain vs loss-framed messages to address drinking among cancer survivors

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
850

participants targeted

Target at P75+ for not_applicable

Timeline
23mo left

Started Mar 2026

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress5%
Mar 2026Mar 2028

First Submitted

Initial submission to the registry

January 16, 2026

Completed
10 days until next milestone

First Posted

Study publicly available on registry

January 26, 2026

Completed
2 months until next milestone

Study Start

First participant enrolled

March 30, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2028

Last Updated

February 25, 2026

Status Verified

February 1, 2026

Enrollment Period

2 years

First QC Date

January 16, 2026

Last Update Submit

February 23, 2026

Conditions

AlcoholCancer

Keywords

alcoholalcohol warning labelscancer survivors

Outcome Measures

Primary Outcomes (3)

  • Change in alcohol-cancer harm perception

    Change in participants' beliefs about experiencing cancer in the future due to alcohol use measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

    Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

  • Intention to Reduce Alcohol consumption

    Change in participants' intention to reduce alcohol consumption in the next month, measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

    Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

  • Commitment to a limited drinking goal in the next month

    Change in participants' intention to commit to a drinking limit goal in the next month, measured on a scale from 1 (not at all) to 5 (a lot). The outcome is the change on the mean score from the pre to post exposure.

    Within 15 minutes on a single online session - from before message exposure (pre-exposure) to after message exposure (post-exposure).

Secondary Outcomes (2)

  • Message perceived effectiveness

    One time (within 5 minutes) post-exposure evaluation.

  • Message Receptivity

    One time (within 5 minutes) post-exposure evaluation.

Study Arms (2)

Gain-framed Messages

EXPERIMENTAL

The study will test in an online 15 minutes single session, four gain-framed alcohol-cancer risk messages. Each message will be viewed in three intensity levels (text-only, neutral image, and graphic image), yielding 12 total message stimuli.

Behavioral: Text-only messagesBehavioral: AI-developed Neutral pictorial messagesBehavioral: AI-developed graphic pictorial messages

Loss-Framed Messages

EXPERIMENTAL

The study will test in an online 15 minutes single session, four loss-framed alcohol-cancer risk messages. Each message will be viewed in three intensity levels (text-only, neutral image, and graphic image), yielding 12 total message stimuli.

Behavioral: Text-only messagesBehavioral: AI-developed Neutral pictorial messagesBehavioral: AI-developed graphic pictorial messages

Interventions

Text-only messagesBEHAVIORAL

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

Gain-framed MessagesLoss-Framed Messages
AI-developed Neutral pictorial messagesBEHAVIORAL

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

Gain-framed MessagesLoss-Framed Messages
AI-developed graphic pictorial messagesBEHAVIORAL

The study will test eight alcohol-cancer risk messages (four gain-framed and four loss-framed). Each message will be developed at three intensity levels (text-only, neutral image, and graphic image), yielding 24 total message stimuli.

Gain-framed MessagesLoss-Framed Messages

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 21 years or older
  • Resident of the United States
  • Able to read and speak English
  • Diagnosed with one of the following cancers: mouth, throat, larynx, liver, colon, rectum, or breast
  • Current alcohol user (≥ 1 alcoholic drink in the past 30 days)

You may not qualify if:

  • Adults unable to consent
  • Individuals younger than 21
  • Not residing in the US
  • Non-alcohol users (\<1 drink)
  • Less than 50% completion of the survey

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Miami

Miami, Florida, 33136, United States

Location

MeSH Terms

Conditions

Neoplasms

Study Officials

  • Taghrid Asfar, MD, MSPH

    University of Miami

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Daniela Avendano, MS

CONTACT

305-915-0061dxa1356@miami.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

January 16, 2026

First Posted

January 26, 2026

Study Start

March 30, 2026

Primary Completion (Estimated)

March 30, 2028

Study Completion (Estimated)

March 30, 2028

Last Updated

February 25, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

US(1)