Lower-Limb Muscle Mass and Balance Performance

NCT07365605 | Completed DMC

• 1 other identifier: E-87914409-050.04-117156
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the interaction between lower-limb muscle mass and balance performance in moderately physically active young men. Body composition parameters, including appendicular skeletal muscle mass, leg muscle mass, and the ratio of lower-limb muscle mass to body weight (LMM/BW), will be assessed using bioelectrical impedance analysis. Balance performance will be evaluated using a center-of-pressure-based static balance test, with classifications derived from sway path length and sway area parameters. Participants will be grouped according to balance performance metrics, and muscle mass indicators will be compared between balance-based groups. Correlation analyses will also be conducted to explore associations between muscle mass variables and balance outcomes across the entire sample. It is anticipated that normalized muscle mass indicators, particularly LMM/BW, will demonstrate greater discriminative sensitivity than absolute muscle mass measures in relation to balance performance. The findings are expected to contribute to a more precise understanding of how relative lower-limb muscular capacity relates to postural control in young, physically active populations.

Conditions

Lower-limb Muscle Mass and Balance Performance

Keywords

Balance performance; Relative muscle mass; Lower-limb muscles; Postural stability

Outcome Measures

Primary Outcomes (1)

• Balance performance assessed by center-of-pressure sway path length

  Balance performance will be quantified using center-of-pressure sway path length recorded during a 30-second quiet standing test on a stabilometric platform. Sway path length will represent the total displacement of the center of pressure over the trial duration, with higher values indicating poorer balance performance. This measure will serve as the primary balance outcome for group classification and for association analyses with lower-limb muscle mass indicators.

  Day 1 (Assessed during a single laboratory testing session)

Study Arms (2)

Lower Balance Performance Group (LBP)

This cohort will include moderately physically active young men who exhibit higher sway path length values during a 30-second center-of-pressure-based static balance test, indicating lower balance performance. Participants in this group will have no musculoskeletal, neurological, or medical conditions affecting postural control. This cohort will be used to examine muscle mass characteristics associated with relatively poorer balance performance.

Higher Balance Performance Group (HBP)

This cohort will include moderately physically active young men who exhibit lower sway path length values during a 30-second center-of-pressure-based static balance test, indicating higher balance performance. Participants in this group will be free from conditions that may influence balance outcomes. This cohort will be used to evaluate muscle mass characteristics associated with relatively better balance performance.

Eligibility Criteria

• Age: 20 Years - 32 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Eskisehir, TURKEY

Sponsors & Collaborators

• Uludag University: lead

Study Sites (1)

Aeromedical Research And Training Center (ARTC)

Eskişehir, Turkey (Türkiye)

Location

Related Publications (5)

• Lesinski M, Hortobagyi T, Muehlbauer T, Gollhofer A, Granacher U. Effects of Balance Training on Balance Performance in Healthy Older Adults: A Systematic Review and Meta-analysis. Sports Med. 2015 Dec;45(12):1721-38. doi: 10.1007/s40279-015-0375-y.

  PMID: 26325622 BACKGROUND

• Granacher, U., Gollhofer, A., & Hortobágyi, T. (2013). Effects of strength training on balance ability in older adults: A systematic review and meta-analysis. Sports Medicine, 43(6), 515-529. https://doi.org/10.1007/s40279-013-0045-y

  BACKGROUND

• Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.

  PMID: 30312372 BACKGROUND

• Calbet JA, Radegran G, Boushel R, Saltin B. On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass. J Physiol. 2009 Jan 15;587(2):477-90. doi: 10.1113/jphysiol.2008.162271. Epub 2008 Dec 1.

  PMID: 19047206 BACKGROUND

• Bohannon RW, Bubela DJ, Magasi SR, Wang YC, Gershon RC. Sit-to-stand test: Performance and determinants across the age-span. Isokinet Exerc Sci. 2010;18(4):235-240. doi: 10.3233/IES-2010-0389.

  PMID: 25598584 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 16, 2026
• First Posted: January 26, 2026
• Study Start: February 26, 2026
• Primary Completion: May 30, 2026
• Study Completion: June 3, 2026
• Last Updated: June 8, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)