Liver Transplant Recipients and 30-Second Lie-to-Sit Test

NCT07365098 | Recruiting

• 1 other identifier: 2025/8550
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper and lower extremity function, exercise capacity, and perceived exertion.

Conditions

Liver Transplant Recipients

Keywords

liver; functional capacity; liver transplant recipients; 30 second lie-to-sit test

Outcome Measures

Primary Outcomes (1)

• 30-second lie-to-sit test

  In this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible. They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded.

  24 hours

Secondary Outcomes (11)

• Waist Circumference

  24 hours

• Modified Borg Scale

  24 hours

• 30-second sit-to-stand test

  24 hours

• Quadriceps muscle strength

  24 hours

• Deltoid muscle strength

  24 hours

Interventions

30-second lie-to-sit test OTHER

In this test, participants will be asked to start from a supine position with their head and arms supported and move to a sitting position as quickly as possible. They will be allowed to use one hand and, if necessary, a thin cushion to help them sit up. The number of repetitions performed within 30 seconds will be recorded.

Modified Borg Scale OTHER

Following the 30-second lie-to-sit test, the modified Borg scale will be used to assess participants' perceived exertion levels.This scale is a standard tool that allows individuals to subjectively assess their level of exertion during physical activity or exercise, rated from 0 (no exertion) to 10 (maximum exertion).

waist circumference OTHER

Waist circumference will be measured in centimeters at the narrowest point between the lowest rib and the upper border of the pelvis while the participant is standing, and the value will be recorded.

30-second sit-to-stand test OTHER

The 30-second sit-to-stand test will be used to assess participants' lower extremity muscle strength and functional capacity. In this test, the participant sits with their back against a chair, feet flat on the floor, and arms crossed over the chest, and stands up and sits down as many times as possible within 30 seconds. Hands should not touch the chair during the test, and only full, complete repetitions are counted. The total number of repetitions at the end of the test will be recorded.

Quadriceps muscle strength OTHER

Quadriceps muscle strength will be measured isometrically using a hand-held dynamometer. The participant will be seated with the knees flexed at 90°. The dynamometer will be placed on the front of the leg at ankle level, and the participant will be asked to lift the leg with maximal effort. Three measurements will be taken for each leg, and the average value will be recorded.

Deltoid muscle strength OTHER

Isometric strength of the deltoid muscle will be assessed using a hand-held dynamometer. The participant will be seated with the shoulder positioned at 90° abduction and the elbow slightly flexed. The dynamometer will be placed on the lateral side of the upper arm at elbow level, and the participant will perform maximum-effort shoulder abduction. Three measurements will be taken for each extremity, and the average value will be recorded.

Trunk flexion strength OTHER

The isometric trunk flexion strength test will be performed with the participant positioned supine, with the knees extented or the hips flexed at 30°. The dynamometer will be placed below the suprasternal notch of the sternum. The participant will place their hands on the opposite acromions and perform isometric trunk flexion.

Trunk extension strength OTHER

The isometric trunk extension strength, the participant will be positioned prone while lying down. The dynamometer will be placed at the T4 level, and the participant will be asked to perform maximum isometric trunk extension. In each test position, participants will first perform a submaximal trial, followed by three correct repetitions, and the average value will be recorded.

Handgrip strength OTHER

Handgrip strength will be assessed using a hand dynamometer. Participants will be seated with their shoulders adducted at the sides, elbows flexed at 90°, forearms in a neutral position, and wrists positioned at 0-30° extension and 0-15° ulnar deviation. Three trials will be performed for each hand, with a 30-second rest between trials. For analysis, the average of three measurements for both hands will be recorded.

2-minute walk test OTHER

The 2-minute walk test will be used to assess participants' exercise capacity and physical performance. During the test, participants will walk at a self-selected, safe pace for two minutes, and the distance covered in meters will be recorded.

Upper Extremity Functional Index-15 (UEFI-15) OTHER

This questionnaire consists of 15 items that assess difficulties in using the upper extremities for activities of daily living. Each item is scored from 0 (cannot do) to 4 (no difficulty). The raw score ranges from 0 to 59 and is converted to a final score ranging from 0 to 100. A higher final score indicates better upper extremity function, providing a comprehensive assessment of functional capacity.

Lower Extremity Functional Scale (LEFS) OTHER

This questionnaire is important for assessing lower extremity functional capacity and examining activity limitations in various lower extremity disorders. It consists of 20 items, each scored from 0 (extreme difficulty or unable to perform the activity) to 4 (no difficulty). Intermediate values are defined as 1 (quite difficult), 2 (moderately difficult), and 3 (somewhat difficult). The total score ranges from 0 to 80, with higher scores indicating better functional level.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

liver transplant recipients

You may qualify if:

• Adults aged 18-65 years
• Diagnosed with end-stage liver disease and listed for liver transplantation
• Ability to speak, understand, and write in Turkish
• No mental disorders
• Voluntary participation with informed consent

You may not qualify if:

• Pulmonary, neurological, or cardiac diseases that may interfere with adherence to the assessment protocol
• Difficulty complying with the assessment program
• Musculoskeletal problems
• History of regular physical activity
• Multiple organ failure
• Cognitive impairment

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Inonu Unıversity

Malatya, Turkey (Türkiye)

RECRUITING

MeSH Terms

Interventions

Waist Circumference

Intervention Hierarchy (Ancestors)

Body Size; Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Anthropometry; Investigative Techniques; Physiological Phenomena

Central Study Contacts

Büşra CANDİRİ

CONTACT

+905073780717; candiri_17@hotmail.com

İrem Yiğit

CONTACT

+905375427930; irem44ahmet@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: January 15, 2026
• First Posted: January 26, 2026
• Study Start: November 8, 2025
• Primary Completion (Estimated): October 20, 2026
• Study Completion (Estimated): December 20, 2026
• Last Updated: January 26, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)