Local Registry of Central Nervous System Infections (ReCeNSI)

NCT07364539 | Recruiting

• 1 other identifier: ReCeNSI
• Study Type: observational
• Target: 520
• Locations: 1 country
• Sites: 1

Brief Summary

Central Nervous System (CNS) infections are considered rare conditions but at the same time, they are emergencies whose diagnosis and treatment are time-dependent. They include several clinical syndromes, including meningitis, encephalitis, brain abscesses, and post-surgical meningitis. The classic triad of symptoms includes fever, altered mental status, and neck stiffness, but other common manifestations include nausea and vomiting, cranial nerve dysfunction, skin rash, and seizures. Due to the potentially life-threatening effects on patients, these clinical conditions cannot be underestimated. The CNS includes the brain and spinal cord, surrounded and protected by the meninges and cerebrospinal fluid (CSF). Within the CNS are numerous nuclei responsible for vital functions, as well as more complex intellectual activities.

Conditions

Central Nervous System (CNS) Infection

Outcome Measures

Primary Outcomes (1)

• To evaluate the outcome in terms of mortality at discharge in patients with CNS infections.

  From January 2012

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In the nine years since 2012, we have identified 260 patients with positive CSF tests. We assume that over the next 10 years we will register the same number of patients, for a total of 520 patients. With this sample size, the precision of the mortality estimate over the study period will be at worst ±4.3%, corresponding to half the 95% confidence interval (CI) of a 50% chance. If the mortality rate were 10%, the precision would be ±2.7%; if the mortality rate were 5%, the precision would be ±2%.

* Pazients admitted to the Fondazione IRCSS Policlinico San Matteo * Diagnosis of bacterial meningitis, meningoencephalitis, bacterial CNS infection, viral CNS infection, viral encephalitis, brain abscess, or post-neurosurgical meningitis.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Fondazione IRCCS Policlinico San Matteo di Pavia: lead

Study Sites (1)

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, Italia, 27100, Italy

RECRUITING

MeSH Terms

Conditions

Infections

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 23, 2026
• Study Start: March 4, 2022
• Primary Completion: March 5, 2022
• Study Completion (Estimated): January 1, 2030
• Last Updated: January 23, 2026

Record last verified: 2025-09

Locations

IT (1)