Effects of Ultrasound-guided Recruitment Manoeuvres on Postoperative Pulmonary Complications in OSA Patients Undergoing Total Laparoscopic Hysterectomy

NCT07362680 | Recruiting

• 1 other identifier: EC-25-117
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the lung-protective effects of ultrasound-guided lung recruitment maneuvers in patients with OSA undergoing total laparoscopic hysterectomy and to explore the efficacy of EELV measurement in assessing the effectiveness of these maneuvers.

Conditions

Total Laparoscopic Hysterectomy; Atelectasis, Postoperative

Outcome Measures

Primary Outcomes (1)

• The lung ultrasound scores of patients after endotracheal intubation (T1), after the first lung recruitment procedure (T2), after the operation (T3), after the second lung recruitment procedure (T4), and 30 minutes after extubation (T5)

  Perioperative

Secondary Outcomes (1)

• Recruitment volume measured by the ΔEELV method

  Perioperative

Study Arms (3)

the SRM group

ACTIVE COMPARATOR

the sustained inflation recruitment maneuver group, n=30

Procedure: the sustained inflation recruitment maneuver

the PRM group

ACTIVE COMPARATOR

the incremental PEEP recruitment maneuver group, n=30

Procedure: the incremental PEEP recruitment maneuver

the URM group

EXPERIMENTAL

the Ultrasound-guided recruitment maneuver group, n=30

Procedure: the Ultrasound-guided recruitment maneuver

Interventions

the sustained inflation recruitment maneuver PROCEDURE

The APL valve on the anaesthesia machine will be adjusted to 30 cmH₂O, and the rapid oxygen inflow valve will be pressed to increase the pressure to the maximum, maintaining the pressure for 30 seconds.

the SRM group

the incremental PEEP recruitment maneuver PROCEDURE

Starting from 5 cmH₂O, PEEP will be titrated upwards in 5 cmH₂O increments every 30 seconds until a maximum of 30 cmH₂O is reached. After maintaining for 40 seconds, PEEP will be decreased by 5 cmH₂O every 30 seconds until it returns to the pre-recruitment level.

the PRM group

the Ultrasound-guided recruitment maneuver PROCEDURE

Lung ultrasound will be performed on patients. If any lung region has an LUS score ≥ 2, ultrasound-guided RM will be performed; otherwise, no operation will be conducted. After the ultrasound examination, the probe will be positioned over the lung region exhibiting the most severe aeration loss (highest LUS) to guide the RMs. The ventilator will be set to pressure-controlled ventilation (PCV), maintaining the inspiratory pressure at 40 cmH₂O. PEEP will be gradually increased from 5 cmH₂O, with increments of 5 cmH₂O every 5-10 seconds, until ultrasound shows no atelectatic areas. The pressure will be maintained at 40 cmH₂O for 40 seconds. An airway pressure ceiling of 40 cmH₂O was established, and the pressure and the time used for the RM will be recorded.

the URM group

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years;
• Scheduled for elective total laparoscopic hysterectomy;
• American Society of Anesthesiologists (ASA) I to III;
• BMI \> 28 kg/m²;
• STOP-BANG score ≥ 3.

You may not qualify if:

• Abnormal findings on preoperative chest X-ray or CT, such as atelectasis, pneumothorax, thoracic deformity, pleural effusion, or neuromuscular diseases;
• Pre-existing severe pulmonary diseases;
• Severe cardiac arrhythmias or a history of cardiac surgery;
• Allergy to any medications used in the study.

Sponsors & Collaborators

• The First Affiliated Hospital of Xinxiang Medical College: lead

Study Sites (1)

The First Affiliated Hospital of Xinxiang Medical College

Xinxiang, Henan, 453100, China

RECRUITING

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2025
• First Posted: January 23, 2026
• Study Start: May 2, 2025
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: January 23, 2026

Record last verified: 2026-01

Locations

CN (1)