Optimizing Hemodialysis: How Low Dialysate Flow Alters Adequacy and Patient Recovery.

NCT07360769 | Completed

• 1 other identifier: 0108861
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to detect if lower dialysate flow rate can affect hemodialysis adequacy , dialysis recovery time and patients quality of life. The main questions it aims to answer are: does low dialysate flow affect hemodialysis adequacy? does green dialysis achievable without affecting hemodialysis adequacy? Researchers will compare hemodialysis session of high dialysate flow to that with low dialysate flow. Participants will: underwent hemodialysis for a week with low dialysate flow and another week with high dialysate flow.

Conditions

End Stage Kidney Disease (ESRD)

Outcome Measures

Primary Outcomes (2)

• The change of dialysate flow rate, for three successive conventional hemodialysis sessions, from 500ml/min to 300ml/min and its impact on hemodialysis adequacy that is assessed by urea reduction ratio (URR).

  Two weeks

• The change of dialysate flow rate, for three successive conventional hemodialysis sessions, from 500ml/min to 300ml/min and its impact on hemodialysis adequacy that is assessed by and single-pool Kt/V (spKt/V) using the Daugirdas formula.

  Two weeks

Secondary Outcomes (2)

• The effect of lowering dialysate flow rate from 500ml/min (milli per minute) to 300ml/min on dialysis recovery time (DRT) in minutes. Longer duration indicates lower dialysis adequacy.

  two weeks

• The patients reported outcome measures that is assessed by palliative care Outcome Scale - Symptoms Renal (POS S renal). Each symptom takes a score from zero to four (0-4), high score indicates less efficient dialysis.

  Tow weeks

Study Arms (1)

ESKD patients

ACTIVE COMPARATOR

Other: lower dialysate flow rate ( 300ml/min). then testing its effect on hemodialysis adequacy

Interventions

lower dialysate flow rate ( 300ml/min). then testing its effect on hemodialysis adequacy OTHER

The aim of this study is to check whether change of dialysate flow from 500ml/min to 300ml/min has a significant impact on dialysis adequacy , dialysis recovery time and patient reported outcome measures in maintenance hemodialysis patients.

ESKD patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ESKD patients more than or equal 18 years old, on maintenance HD thrice weekly for more than three months and each session lasts for 4 hours.
• All patients will receive HD via an arterio-venous fistula.
• All patients will receive HD via the same type of HD machine and the blood pump will be set at 300ml/min.
• All patients will receive the same type of HD membranes and every effort will be made to achieve the dry weight of the patients.

You may not qualify if:

• Critically ill and hospitalized ESKD patients.
• Mentally disabled patients.
• Patients with terminal malignancy or receiving chemotherapy.
• Patients receiving immune suppression treatment.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Faculty of Medicine Alexandria University

Alexandria, Egypt

Location

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2025
• First Posted: January 22, 2026
• Study Start: June 1, 2025
• Primary Completion: August 30, 2025
• Study Completion: September 30, 2025
• Last Updated: January 22, 2026

Record last verified: 2025-03

Locations

EG (1)