NCT07360249

Brief Summary

The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
3mo left

Started Jan 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress57%
Jan 2026Aug 2026

First Submitted

Initial submission to the registry

January 14, 2026

Completed
Same day until next milestone

Study Start

First participant enrolled

January 14, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 22, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2026

Expected
Last Updated

January 22, 2026

Status Verified

January 1, 2026

Enrollment Period

4 months

First QC Date

January 14, 2026

Last Update Submit

January 14, 2026

Conditions

Exercise Metabolism

Outcome Measures

Primary Outcomes (1)

  • Exogenous carbohydrate oxidation rate (g/h)

    Total exogenous carbohydrate oxidation rate (g/h) over 180 minutes

    180 minutes

Secondary Outcomes (8)

  • Peak exogenous carbohydrate oxidation rate (g/h)

    180 minutes

  • Whole-body carbohydrate oxidation rate (g/h)

    180 minutes

  • Endogenous carbohydrate oxidation rate (g/h)

    180 minutes

  • Whole-body fat oxidation rate (g/h)

    180 minutes

  • Blood lactate concentrations (mmol/L)

    180 mninutes

  • +3 more secondary outcomes

Other Outcomes (1)

  • Exogenous carbohydrate oxidation over 2 hours (g/h)

    120 minutes

Study Arms (2)

One to One ratio

EXPERIMENTAL

Glucose and fructose ingestion in a one-to-one ratio

Other: Glucose and fructose (one-to-one)

Two to one ratio

ACTIVE COMPARATOR

Glucose and fructose ingestion in a two-to-one (1-to-0.5) ratio

Other: Glucose and fructose (two-to-one)

Interventions

Glucose and fructose (one-to-one)OTHER

Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)

One to One ratio
Glucose and fructose (two-to-one)OTHER

Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)

Two to one ratio

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age: 18 years and above;
  • Performing endurance training for at least 5 hours per week
  • Capable of three hours of continuous exercise

You may not qualify if:

  • Glucose or lipid lowering, or weight loss medication
  • Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
  • Contraindications to exercise
  • Pregnant or lactating

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Bath

Bath, Bath, BA2 7AY, United Kingdom

RECRUITING

MeSH Terms

Interventions

GlucoseFructose

Intervention Hierarchy (Ancestors)

HexosesMonosaccharidesSugarsCarbohydratesKetoses

Central Study Contacts

Javier Gonzalez

CONTACT

+441225385518j.t.gonzalez@bath.ac.uk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Nutrition and Metabolism

Study Record Dates

First Submitted

January 14, 2026

First Posted

January 22, 2026

Study Start

January 14, 2026

Primary Completion

May 1, 2026

Study Completion (Estimated)

August 1, 2026

Last Updated

January 22, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will share

Outcome measures in anonymised format.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Upon publication in a peer-reviewed journal
Access Criteria
Via the University of Bath Research Data Repository

Locations

GB(1)