PENG Block & PENG PRF

NCT07360093 | Recruiting

• 1 other identifier: E2-2613941
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of this study is to prospectively compare the effects of the pericapsular nerve group (PENG) block alone and the combination of PENG block with pulsed radiofrequency (PRF) on pain intensity in patients with chronic hip pain. As a secondary aim, the effects of both treatment modalities on hip function are intended to be evaluated using valid and reliable functional assessment scales. Through this study, it is aimed to demonstrate the clinical contribution of adding PRF to the PENG block and to identify a more effective and longer-lasting approach for the interventional treatment of chronic hip pain.

Conditions

Osteoarthritis (OA) of the Hip

Keywords

Osteoarthritis, Hip,; Pain, Chronic; Nerve Blockade; Pulsed Radiofrequency Treatment

Outcome Measures

Primary Outcomes (1)

• Change in pain intensity measured by the Visual Analog Scale (VAS, 0-10; higher scores indicate worse pain)

  Pain intensity will be assessed using the Visual Analog Scale (VAS), a validated pain measurement tool ranging from 0 to 10, where 0 indicates no pain and 10 represents the worst pain imaginable.

  baseline (pre-procedure) and at 1 week, 1 month, 3 months, and 6 months after the procedure.

Secondary Outcomes (3)

• Change in Pain, Stiffness, and Physical Function Measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, 0-96)

  baseline (pre-procedure) and at 1 week, 1 month, 3 months, and 6 months after the procedure.

• Change in Hip Function Measured by the Harris Hip Score (HHS, 0-100)

  Baseline (pre-procedure), 1 week, 1 month (primary functional endpoint), 3 months, and 6 months after pulsed radiofrequency (PRF) treatment.

• Secondary Outcome: TAnalgesic Use

  Baseline and at 1 week, 1 month, 3 months, and 6 months post-intervention

Study Arms (1)

Group PENG

The initial step in patients diagnosed with chronic hip pain is a diagnostic intervention, namely the application of a pericapsular nerve group (PENG) block. In patients who benefit from the diagnostic block-defined as a reduction of 50% or more in VAS scores following the procedure-pulsed radiofrequency (PRF) treatment is added as a second-stage intervention. This stepwise approach reflects standard clinical practice, and both procedures are commonly used in clinical praqctice for the management of chronic hip pain. However, the available evidence in the literature on this approach is largely limited to case reports and retrospective case series. The aim of the present study is to document and share the clinical outcomes of this treatment strategy routinely applied in clinical practice.

Procedure: PENG Block Pulsed radiofrequency

Interventions

PENG Block Pulsed radiofrequency PROCEDURE

This intervention consists of a stepwise, two-stage treatment protocol routinely applied in our clinical practice for the management of chronic hip pain. In the first stage, all patients undergo an ultrasound-guided pericapsular nerve group (PENG) block as a diagnostic and therapeutic procedure. Pain intensity is assessed using the Visual Analog Scale (VAS) following the diagnostic block. Only patients who demonstrate a clinically meaningful response, defined as a reduction of 50% or greater in VAS scores, proceed to the second stage of the intervention. In the second stage, pulsed radiofrequency (PRF) treatment is applied to the same target region in addition to the PENG block, aiming to achieve longer-lasting analgesia through neuromodulation without tissue destruction.

Group PENG

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

18-80 years old with chronical hip pain

You may qualify if:

• Presence of chronic hip pain lasting at least 3 months
• Baseline Visual Analog Scale (VAS) score ≥ 4
• Clinical and/or radiological diagnosis of hip osteoarthritis
• Inadequate response to conservative treatments

You may not qualify if:

• Local or systemic infection at the intervention site
• Coagulopathy or inability to discontinue anticoagulant therapy
• Hip pain related to malignancy
• History of previous hip arthroplasty
• Severe neurological deficit
• Pregnancy or breastfeeding

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, 06680, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Jadon A. Pulsed Radiofrequency (PRF) of Pericapsular Nerves Group (PENG) in Chronic Hip Pain-A Case Report. Turk J Anaesthesiol Reanim. 2021 Dec;49(6):490-493. doi: 10.5152/TJAR.2021.1080. PMID: 35110031; PMCID: PMC9472694.

  BACKGROUND

• 10.5152/TJAR.2021.21230

  BACKGROUND

MeSH Terms

Conditions

Osteoarthritis; Osteoarthritis, Hip; Chronic Pain

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ulku Sabuncu MD, Assoc. prof.

CONTACT

+905337085212; sabuncuulku@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: January 14, 2026
• First Posted: January 22, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 28, 2027
• Last Updated: March 18, 2026

Record last verified: 2026-03

Locations

TU (1)