Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery

NCT07359469 | Completed

• 2 other identifiers: FR-CP01EDONA-UPNA-2025
• Study Type: observational
• Target: 118
• Locations: 1 country
• Sites: 1

Brief Summary

Thoracic surgery often produces severe postoperative pain due to nerve injury and inflammation. Effective pain control is essential to reduce complications and opioid use. This prospective observational cohort study evaluated adult patients undergoing pulmonary resection by thoracotomy or video-assisted thoracoscopic surgery (VATS). The study examined whether intraoperative administration of intravenous lidocaine, ketamine, and magnesium, used as part of multimodal analgesia, was associated with reduced postoperative morphine consumption and lower early postoperative pain scores. Outcomes included 24-hour morphine use, pain intensity at 3 and 24 hours, complications, and chronic pain at 3 months. No study-directed interventions were performed; anesthetic management followed routine clinical practice.

Conditions

Postoperative Pain; Thoracic Surgery; Multimodal Analgesia; Opioid Consumption, Postoperative

Keywords

Multimodal analgesia; Lidocaine; Ketamine; Magnesium sulphate; Opioid consumption; VAS pain score; thoracotomy; VATS surgery

Outcome Measures

Primary Outcomes (1)

• Total intravenous morphine consumption within the first 24 hours postoperatively.

  Total amount of intravenous morphine administered during the first 24 postoperative hours. Values will be recorded in milligrams (mg). Higher values indicate greater opioid consumption.

  First 24 postoperative hours

Secondary Outcomes (1)

• Pain intensity at 3 and 24 hours postoperatively, assessed using a 10-point Visual Analogue Scale (VAS), chronic pain ( 3 months)

  3 hours, 24 hours, and 3 months after surgery

Other Outcomes (1)

• Safety Outcomes

  Perioperative period (day of surgery through postoperative day 7) and at 3 months

Study Arms (2)

Lidocaine-Ketamine-Magnesium Group (LKM)

Adult patients undergoing elective pulmonary resection who received intraoperative multimodal analgesia including continuous infusions of lidocaine, ketamine, and magnesium according to institutional protocol.

Standard Analgesia Control Group

Adult patients undergoing elective pulmonary resection who received standard intraoperative analgesia without lidocaine, ketamine, or magnesium infusion.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective pulmonary resection (thoracotomy or video-assisted thoracoscopic surgery) at University Hospital Dr. Josep Trueta. The study population includes individuals receiving standard perioperative analgesic management and monitored in the postoperative care unit. Patients represent a typical thoracic surgery clinical population treated in routine practice.

You may qualify if:

• Adults aged 18 years or older.
• Scheduled for elective pulmonary resection (thoracotomy or VATS).
• Able to provide informed consent.
• ASA physical status I-IV.

You may not qualify if:

• Emergency surgery.
• Known allergy or contraindication to lidocaine, ketamine, or magnesium.
• Severe hepatic insufficiency.
• Severe renal dysfunction (eGFR \< 30 mL/min/1.73 m²).
• Pre-existing significant arrhythmias (e.g., uncontrolled atrial fibrillation, ventricular arrhythmias).
• Pregnancy.
• Cognitive impairment preventing valid informed consent.
• Patients receiving chronic intravenous analgesics or regional anesthesia techniques preoperatively.

Sponsors & Collaborators

• Universidad Pública de Navarra: lead

Study Sites (1)

University Hospital Dr. Josep Trueta

Girona, 17007, Spain

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Manuel Murie Fernandez, MD, PhD

  Universidad Pública de Navarra ( UPNA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: January 22, 2026
• Study Start: January 1, 2018
• Primary Completion: February 3, 2022
• Study Completion: May 3, 2022
• Last Updated: January 22, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)