NCT07357883

Brief Summary

Effect of Argan oil vs placebo on healing after laser depigmentation

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Oct 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 29, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 22, 2025

Completed
19 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 10, 2026

Completed
4 days until next milestone

First Submitted

Initial submission to the registry

January 14, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 22, 2026

Completed
Last Updated

January 22, 2026

Status Verified

January 1, 2026

Enrollment Period

2 months

First QC Date

January 14, 2026

Last Update Submit

January 14, 2026

Conditions

Gingival HyperpigmentationLaser DepigmentationTopical Argan OilPostoperative Gingival Healing

Keywords

Laser depigmentationpostoperative healingtopical argan oil

Outcome Measures

Primary Outcomes (1)

  • Effect of Argan oil

    Evaluate the effect of Argan oil vs. placebo on post-operative Gingival healing

    14 days

Secondary Outcomes (1)

  • Visual Analog Scale (VAS)

    14 days

Study Arms (2)

Topical Argan Oil

EXPERIMENTAL

Applied post-laser depigmentation

Procedure: Laser Depigmentation

Reference placebo

PLACEBO COMPARATOR

Identical placebo formulation

Procedure: Laser Depigmentation

Interventions

Laser DepigmentationPROCEDURE

Laser protocol: Diode laser, wavelength 810-980 nm, continuous mode, initiated fiber tip 400 µm, power 1.5-2 W.

Reference placeboTopical Argan Oil

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Patients aged 18-40 with moderate/severe physiological gingival pigmentation
  • Good general and periodontal health.

You may not qualify if:

  • Systemic diseases affecting healing (e.g., uncontrolled diabetes).
  • Smokers or tobacco chewers.
  • Pregnant/lactating women.
  • Previous depigmentation procedures in the last 2 years.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Dentistry, Cairo University

Cairo, Cairo Governorate, Egypt

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Lecturer - Periodontology Department - Faculty of Dentistry - Cairo University.

Study Record Dates

First Submitted

January 14, 2026

First Posted

January 22, 2026

Study Start

October 29, 2025

Primary Completion

December 22, 2025

Study Completion

January 10, 2026

Last Updated

January 22, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)