NCT07357337|CompletedPhase 4DMC
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Sponsor study identifier
interventional
68
1 country
1
Study Start
February 15, 2025
Actual (reported)Primary Completion
August 10, 2025
Actual (reported)Study Completion
October 1, 2025
Actual (reported)The goal of the clinical trial is to learn if oral metformin works to treat moderate to severe acne vulgaris. Investigators will compare this drug to oral doxycycline to see if this drug works to treat acne. All participants will be divided into two groups. Group A will be given oral Metformin 500 mg to be taken twice daily, while Group B patients will be given oral Doxycycline 100 mg once daily. They will be assessed by the scoring method Total Lesion Count (TLC) and the Global Acne Grading System (GAGS) at each follow-up (i.e., at 0, 8, and 12 weeks). Efficacy will be measured by using the scoring system GAGS, TLC. The final assessment will be done at the 12th-week follow-up. A total of 68 patients fulfilling the inclusion criteria are enrolled in the study. The efficacy of oral metformin vs oral doxycycline will be measured in all selected patients suffering from acne vulgaris by estimating improvement in the total lesion count (TLC) and the Global Acne Grading (GAGS) assessment score at each follow-up.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 1, 2025
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 15, 2025
Actual (reported)August 10, 2025
Actual (reported)October 1, 2025
Actual (reported)January 6, 2026
Actual (reported)January 22, 2026
Actual (reported)Total lesion count
change in lesion count over the course of 12 weeks of treatment, with responses assessed at baseline, 4 weeks, and 12 weeks.
Global Acne Grading System (GAGS)
Responses will be assessed at baseline, 4 weeks, and 12 weeks
Group A will receive oral tablet Metformin 500mg twice daily
Group B will receive oral tablet Doxycycline 100mg once daily
Intervention group will recieve oral tablet Metformin 500mg twice daily
Group B will receive oral tablet Doxycycline 100mg once daily
Ghurki Trust Teaching Hospital
Lahore, Punjab Province, Pakistan
Habeshian KA, Cohen BA. Current Issues in the Treatment of Acne Vulgaris. Pediatrics. 2020 May;145(Suppl 2):S225-S230. doi: 10.1542/peds.2019-2056L.
Sadati MS, Yazdanpanah N, Shahriarirad R, Javaheri R, Parvizi MM. Efficacy of metformin vs. doxycycline in treating acne vulgaris: An assessor-blinded, add-on, randomized, controlled clinical trial. J Cosmet Dermatol. 2023 Oct;22(10):2816-2823. doi: 10.1111/jocd.15785. Epub 2023 May 2.
Dr. Tahreem Alam Buzdar
Ghurki Trust Teaching Hospital
Prof. Dr. Haroon Nabi
Lahore Medical and Dental College
Dr Aliza Hamadani
Lahore Medical and Dental College
Dr. Ayesha Asad Chattha
Ghurki Trust Teaching Hospital
68 participants (actual enrollment reported by the registry).
First Submitted
January 6, 2026
First Posted
January 22, 2026
Study Start
February 15, 2025
Actual (reported)Contact the study team to confirm eligibility.
Deng Y, Jiang S, Huang Y, Tan X, Huang Y, Chen L, Xu J, Xiong X, Zhou J, Xu Y. Metformin contributes to the therapeutic effects of acne vulgaris by modifying the gut microbiome. Dermatologic Therapy. 2023;2023(1):9336867.
Lee JK, Smith AD. Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris. Dermatol Online J. 2017 Nov 15;23(11):13030/qt53m2q13s.
Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020 Apr 1;10(1):5754. doi: 10.1038/s41598-020-62715-3.
Dr. Iram Kausar
Ghurki Trust Teaching Hospital
Primary Completion
August 10, 2025
Actual (reported)Study Completion
October 1, 2025
Actual (reported)Last Updated
January 22, 2026
Record last verified: 2026-01
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Source: ClinicalTrials.gov.
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